Optimizing medicine use for people who are homebound: an evaluation of a pilot domiciliary Medicine Use Review (dMUR) service in England.

BACKGROUND: As global life expectancy increases, older people with chronic diseases are being required to manage multiple and complex medicine regimes. However, polypharmacy raises the risk of medicine-related problems and preventable hospital admissions. To improve medicine use, English community pharmacies are commissioned to deliver Medicines Use Reviews (MURs), which are typically delivered from the pharmacy. People who are homebound rarely receive the service. This paper describes the uptake and impact of a pilot project that seeks to provide domiciliary Medicines Use Reviews (dMURs).
METHODS: Participating pharmacists collected data on their dMUR activity over a 12-month period. Outcome measures (eg, adherence, side-effects, pharmacist assessment of preventable hospital admissions) were recorded. Pharmacists were also invited to submit written testimonies of their experiences of undertaking dMURs.
RESULTS: Out of 433 possible pharmacies eligible to take part in the pilot, 186 pharmacies expressed an interest, and 91 actively engaged in providing the dMUR service. The total number of dMURs performed were 1092 (mean number performed by each pharmacy was 12). Two thirds of patients reported problems and concerns about side-effects and missed doses regarding their medicines. Pharmacists' assessment to prevent hospital admissions found that over one-third of the dMURs had contributed towards preventing either a possible or likely emergency hospital admission. Twelve pharmacists' testimonies were submitted providing context of the problems patients faced with medicines. DISCUSSION: dMURs are feasible and improve patient medicines use. The results indicate that dMUR potentially prevents hospital admissions and readmissions. dMURs offer an opportunity to support the self-care agenda and ensure homebound patients can successfully manage their medicines.

Introduction

The world’s population is rising and aging. The World Health Organization (WHO) estimates that, between 2015 and 2050, the proportion of the world’s population over 60 years will nearly double from 12% to 22%, and that the number of people aged 60 years and older will outnumber children younger than 5 years.1 For European health systems, it is acknowledged that an aging population, coupled with low birth rates and a higher life expectancy, is one of the greatest social, economic, and public health challenges of the 21st century.2 With little evidence to suggest that older people today are experiencing better health than their parents, aging brings with it an inevitable rise in chronic health conditions.1 People with such medical conditions are the most intensive users of the most expensive health services.3 The global response to the epidemiological and economic impact of aging and associated morbidity has been described as inadequate.4 Innovative solutions are, therefore, needed to ensure older people have equitable access to good quality healthcare, and adequate support to manage their chronic long-term medical conditions.

Given the rising numbers of older people with chronic conditions, polypharmacy is becoming more prevalent. The burden of taking multiple medications is associated with greater healthcare costs, increased risk of adverse drug events (ADEs) and drug-interactions, reduced functional capacity, and medication non-adherence.5 Multi-morbidities and the accompanying polypharmacy have the potential to increase the risk of drug interactions and adverse drug reactions, together with impairing medication adherence and reduction in quality-of-life for patients.6,7 Work undertaken to optimize safe medication use highlights the value of appropriate polypharmacy (all medicines clinically indicated and accepted by the individual as improving their wellbeing), but cautions about problematic polypharmacy (multiple medicines inappropriately prescribed or where the intended benefits are not realized).7 Reconfiguring health professional roles and responsibilities is, therefore, necessary to ensure that medicines are used effectively. In the case of pharmacy, there has been an evident shift in the pharmacist’s role, from the supply of medicines and provision of patient education involving acute medicines, towards consultation-type services for chronic medications.8

The English community pharmacy contractual framework is divided into essential, advanced, and locally commissioned services. Essential services include dispensing medicines and appliances and disposal of unwanted medicines, whereas the “advanced” services include consultation-style Medicine Use Reviews (MURs). MURs were commissioned in 2005, and give community pharmacists an opportunity to contribute to medicines optimization.9,10 However, MURs are typically delivered from a community pharmacy, and patients who are homebound may not be receiving the service.11 A domiciliary Medicines Use Review (dMUR) service was, therefore, designed, and this paper reports the uptake of dMUR by pharmacy teams, investigates the impact of the dMUR on medicines optimization (eg, patient reported adherence to medicines and side-effects, etc.), and presents the lessons that have been learned about commissioning such services in the future.

Medicines Use Reviews (MURs)

An MUR typically involves an annual face-to-face patient–pharmacist consultation to improve the patient’s knowledge of prescribed and over-the-counter medicines and their use (Box 1). Pharmacies are currently entitled to claim a fee of £28 for each MUR they undertake with patients, and are able to conduct up to a maximum of 400 reviews annually. In 2011, the MUR specifications were changed in order to target more vulnerable patients. Under the new terms, at least 50% of all MURs undertaken by each pharmacy should be with patients within these groups (from April 1, 2015 this was raised to at least 70%): (1) patients taking medicines associated with hospital admissions (non-steroidal anti-inflammatory drugs, anticoagulants, antiplatelets, diuretics); (2) patients recently discharged from hospital and who have had changes made to their medicines; and (3) patients with respiratory disease. A fourth target group was agreed in September 2014 (cardiovascular risk) and was implemented from January 1, 2015.

The domiciliary MURs (dMURs) pilot

A dMUR service was developed and led by the NHS England Local Professional Network Chair (Pharmacy), in response to concerns that the target groups did not include patients who are homebound. The dMUR was, therefore, specifically designed to target people unable to attend the pharmacy, ie, homebound patients and those who were not receiving care from a residential/nursing home. Patients could self-refer, or be identified by their pharmacists, GPs, carers, or secondary care professionals. Patients were required to provide written informed consent to the service delivery. This also included consent for anonymized data to be collected and evaluated.

Patients were eligible for a dMUR if they were taking at least six medicines rather than only two as per the MUR. This change to the original service specification was made on the understanding that, first, patients taking a greater number of medicines tend to experience more problems,13,14 and, second, the minimum number of medicines was increased to discourage “gaming,” which has been highlighted by others, where pharmacists opportunistically select patients on fewer medicines that can be conducted quickly and conveniently.15,16 As part of the dMUR, pharmacists were encouraged to review the ordering, collection, and delivery systems for these patients. To be able to offer the service, pharmacists were required to have completed an enhanced Disclosure and Barring Service check, which was paid for by the local NHS England Direct Commissioning Operations (DCO) team.

Services offered by a pharmacy often require additional pharmacist’s time or resources, and it has been suggested that this should be considered in developing a new service.17 For example, one study describing how pharmacists spent their time in practice found that pharmacists spent the majority of their time on many technical aspects of the dispensing process, as opposed to cognitive, patient-centered, tasks.18 It is acknowledged that there might also be barriers to pharmacists being able to conduct dMURs as they would be unable to supervise pharmacy activities, including sales of over-the-counter medicines. Some have suggested that role clarity and professional responsibility need to be considered when designing changes to supervision.19 To ensure sufficient remuneration was in place to try to overcome the barriers to participation, the dMUR service included an additional £56 reimbursement, in addition to the standard MUR payment (£28).

The MUR aims, with the patient’s agreement, to improve his or her knowledge and use of drugs. This purpose is to be achieved through:

Establishing the patient’s actual use, understanding about, and experience of taking his or her medications;

Identifying, discussing, and resolving poor or ineffective use of medicines by the patient;

Identifying side-effects and drug interactions that may affect patient compliance; and

Improving the clinical and cost-effectiveness of prescribed medicines, thereby reducing the wastage of such drugs.12

Abbreviation: MUR, Medicine Use Review.

Methods

The dMUR service was advertised to all pharmacies commissioned by the local NHS England office, across an area covering the geography of ten clinical commissioning groups. It was also advertised through the Local Pharmaceutical Committee website and a mail shot from the NHS England contracting team. Pharmacies within the Nottinghamshire and Derbyshire region that expressed interest were provided with a detailed service specification and guidance, in the form of a simple checklist which included advice on what to do before the visit (eg, confirming appointment times, appropriate paperwork, journey guidance, ie, having a satnav). Advice was also provided on useful equipment that may be necessary (eg, bringing with them clinical waste buckets), and suggestions for taking healthy lifestyle leaflets.

Data collection

Pharmacists collected data on their dMURs over a 12-month period from April 2016 to March 2017. During the dMUR, pharmacists recorded several outcome measures using a pragmatic instrument on a paper template. Demographic data was collected, as well as medicines-related outcomes (eg, patient reported problems with medicines, side-effects, and adherence). In addition, pharmacists used a quantitative scoring method to self-assess the risk that a patient had of a hospital admission, and the impact the dMUR had on reducing this risk. The scoring system, which was devised by the pilot lead, was as follows:

Score 1 = no likelihood of emergency hospital admission prevented.

Examples include: providing a compliance device to aid administration of eye drops; stopping any unnecessary food supplements; providing lifestyle and diet advice.

Score 2 = possible prevention of emergency hospital admission.

Examples include: advising on tackling poor inhaler technique; advising on how best to manage long-term steroid use; suggesting prescribing guidance, such as commencement of bisphosphonates.

Score 3 = likely to prevent an emergency hospital admission.

Examples include: incorrect insulin usage leading to diabetic related complications; poor adherence to antiepileptic medicines. The scoring system helped to analyse baseline data on the potential of the dMUR being able to prevent hospital admissions or possible readmissions.

Upon completion of the dMUR, pharmacists recorded any actions as a result of the dMUR (eg, provision of patient education, referrals to other health professionals).

To evaluate the service further, all participating pharmacists were asked to qualitatively report their dMUR experiences through written reflective testimonials. In particular, we wanted to understand the problems patients had encountered, as well as the solutions pharmacists offered. This was an optional element, in addition to the quantitative data they were required to complete.

Survey data analysis

All the information recorded by pharmacists was inputted into an electronic database (PharmOutcomes®) for analysis. PharmOutcomes is a web-based system which helps commissioners audit and manage pharmacy services. Following data entry and cleaning, summary demographics and characteristics of the sample were initially described. All variables were categorical. The demographic variables were then summarized using frequencies and proportions for the categorical variables. For the outcome variables of interest, the proportion responding positively was computed alongside its 95% confidence interval.

Data analysis of testimonials

Submitted testimonies were then collated, analyzed, and coded inductively by AL and BM. Codes were constructed based upon what was reported and coded extracts systematically read through, and the contents were condensed so that all the different issues raised were recorded. Consideration was then given to how these issues might be grouped together in broader themes, which were then synthesized and narrated.

Ethical approval

The dMUR service was approved by the NHS England DCO team. Being a service evaluation, Health Research Authority ethical approval was not necessary.

Results

Out of a total 433 possible pharmacies eligible to take part in the pilot, 186 pharmacies expressed interest. Of these, 91 actively engaged in providing the dMUR service. The majority of patient recruitment was through community pharmacies (91.7%) (Table 1), and the total number of dMURs performed were 1092 (mean number of dMURs performed by each pharmacy = 12).

Table 1

Demographic data (n=1062)

Variable	Sample proportion	% Positive
Age
<24	6	0.6
25–34	1	0.1
35–44	5	0.5
45–54	21	2.0
55–64	50	4.7
65–74	162	15.2
75+	817	76.9
Gender
Female	722	68
Male	340	32
Ethnicity
White – British	947	89.2
White – Irish/Other	27	2.5
Black or Black British – Caribbean	15	1.4
Asian or Asian British – Pakistani/Other	7	0.7
Prefer not to say/Not stated	52	4.9
Missing data	14	1.3
Possible care arrangements (all that apply)
None	423	39.8
Family	468	44.1
Daily visits by Care Agency	162	15.3
Informal carer/friend	95	8.9
Periodic District Nursing	60	5.6
Service referral by
Community Pharmacy	974	91.7
Patient/patient’s representative	30	2.8
GP practice	28	2.6
Social Services (Community Care Team)	14	1.3
Secondary care	8	0.8
Other (eg, 0 district nurses)	8	0.8

Demographic data (Table 1)

The majority of the patients were female (68%), over the age of 75 (76.9%), and categorized as White British (89.2%). The majority of the carer arrangements were through the family (44.1%), over a third did not have any arrangements (39.8%), and over a quarter (29.8%) had either daily visits by care agencies, informal carers/friends, or periodic district nursing visits.

Medicine-related outcomes from dMUR (Table 2)

Approximately two thirds of patients reported problems and concerns, side-effects, and missed doses regarding their medicines (63.7%). Over a quarter of patients (27.8%) were also identified as having stock piles of medicines or expired medicines, which were consequently removed by the pharmacists.

Pharmacists’ actions following the dMUR (Table 3)

Over half of patients receiving a dMUR (584) received patient advice with their medicines. Over 40% of patients (42.5%) were reviewed for medicine support (eg, medicines delivery). More than half of patients had assessments to improve medicines’ adherence (eg, a review of compliance, inhaler technique, large print labels, etc.).

In addition to the dMUR, two thirds of patients received a medicines’ cabinet check and/or had their medicines synchronized. Approximately one quarter of patients were referred to their GP, social care, hospital support service, or district nurse team.

Analysis of the pharmacists’ assessment to prevent hospital admissions found that over one third (35.3%) had either contributed towards preventing either a possible or likely emergency hospital admission.

Pharmacists’ testimonies

A total of 12 pharmacists’ testimonies were analysed. Every pharmacist reported and described problems around the patients’ medication. These ranged from minor issues (ie, simple advice on inhaler technique) to more substantial concerns over medicine non-adherence, confusion over dosage regimens, and problems with medicines at the primary–secondary interface. In addition to medicines-related problems, pharmacists also identified problems beyond the scope of the dMUR such as catheter and stoma complications.

Problems with medicines

Pharmacists highlighted a range of medication issues in the testimonies. Non-adherence and other medicines optimization issues were resolved using patient education, applying compliance aids, or referring the patient to their GP:

Her inspiration force was far too high … and hitting the back of her throat. After training, we managed to reduce the inspiration force and improve inhaler technique. SU was also taking two Lansoprazole capsules, instead of the one capsule daily as prescribed … SU was also very confused what Atorvastatin was for and how to take it. Therefore, I advised SU why she was taking it and how to take it. [SU Pharmacist]

Also, the patient was confused as to whether he should be taking his ferrous tablets still or not. As a result, I referred this issue to his GP to ascertain whether ferrous tablets were required still or not. [Pharmacist (1)]

Managing side-effects

Most pharmacists’ accounts mentioned that the patient was experiencing side-effects from their prescribed medicines. Pharmacists were able to both assess and address these issues, and so improve medicine adherence:

Since starting the chemotherapy/Enoxaparin, the patient had been suffering from a severe allergy/itching. It was so severe that the patient was prepared to stop the chemotherapy so that the patient can live without the side-effects. She had been given Eurax® cream to help control the itchiness, but it was now becoming more wide-spread, so I advised to take cetirizine as well. I then chased up the patient a few days later, who said it was making a huge difference! The patient is now happy to continue with her chemotherapy. [Pharmacist (2)]

Also, his Spiriva was causing the patient to develop a dry mouth from the inhaler. As a result, I advised the patient to rinse his mouth out and increase fluid intake. His GP had already advised the patient to increase fluid intake, so I asked him to drink a glass of water in between his cups of tea. RM also smokes, so I have signposted him to the New Leaf service currently available in Nottinghamshire. [Pharmacist (3)]

Prevention of possible hospital admissions and readmissions

Commentaries also revealed how the pharmacist intervened to prevent serious adverse drug events and how this led to possible prevention of a hospital admission, particularly, lack of knowledge around medicines and, thus, compliance related problems. Findings also revealed the dMUR to have had an impact on the prevention of potential hospital re-admissions. In these cases, pharmacists identified where medicine reconciliation had failed, and intervened to rectify the problem:

This dMUR visit probably stands out the most as being the most alarming visit I have carried out. When I was going through her medication list, she couldn’t name any medicines she was taking, what they were for, or when she takes any (…) cabinet in the living room and said “I just take a selection of five tablets from this tray,” which was very concerning, as she could potentially take five of the same tablets (…) This visit enabled us to identify a big issue with compliance and patient safety that was “under the radar” for a while, resulting in potentially avoiding an inevitable hospital admission. [Pharmacist (4)]

This patient was completely confused. She didn’t know whether to keep on taking Warfarin after her hospital discharge. (…) Also, she had bisoprolol on her discharge letter, but didn’t have any at home. (…) This visit would have most probably prevented the patient being admitted to hospital again, as without this the patient would have not been taking her Warfarin or bisoprolol. [Pharmacist (5)]

Discussion

The evaluation of the dMUR pilot suggests that this program is feasible, and that pharmacists were able to adopt the dMUR within their practice. Analysis of the results suggest that the dMUR was successful at improving medicine adherence, managing side-effects and reducing medication errors. In the elderly, the burden of multiple medications has been associated with greater healthcare costs and an increased risk of ADEs, drug-interactions, medication non-adherence, reduced functional capacity, and multiple geriatric syndromes.5 The Murray review and the community pharmacy forward view have highlighted the role that community pharmacists could play in managing patient’s medicines, and facilitation of personalized and integrated care for patients with long-term conditions.20 One such role is the community pharmacy is the MUR service. However, it has been recognized that the current service framework is not addressing the needs of older people who are homebound, and that local adaptation of the MUR service to encourage pharmacists to target this subgroup of patients could be a way of improving care. Others have suggested that patients who are homebound could be less likely to be able to access the MUR service, and so are more likely to be disadvantaged when compared to the general population.21 The dMUR service may address the well-known issues that homebound people face in leaving the home and having varying degrees of confinement.22 A lack of contact with the healthcare system and other social interactions can also make people progressively more ill, lonely, and depressed.23

The results also support the growing notion that pharmacists can play a significant role in reducing hospital admissions and readmissions.13,14 This is important, because it is well recognized that transferring patients between care providers, such as on hospital admission or discharge, represents a high-risk area period, potentially leading to adverse drug events. For example, It has been found that around half of the medication errors that occur in hospital are estimated to occur on admission or discharge.24 Medication reconciliation at transitions of care (admission, transfer, and discharge) aims to ensure the correct medications are supplied to the patient at all transition points, avoid medication errors such as omissions, duplications, dosing errors, or drug interactions, and, therefore, to promote seamless care.25 In the present study, most patient were referred by the pharmacist. In order to improve rates of referrals from other health professionals, the value of dMURs should be more widely promoted. In addition, it has been suggested that the current provisions for post discharge MURs are more likely to disadvantage older people, particularly those who are homebound.26

Further research is needed to validate the findings of this pilot, to explore the barriers to service update and establish whether the dMUR service is cost-effective.

Strengths and limitations

This pilot study shows that dMURs reduce the perceived risk of medicine-related hospitalization and that the intervention was found to be feasible in practice. This finding should be viewed with caution as the tool used to collect information about the dMUR service and the score of hospital admission risk was not validated. Furthermore, we do not know how this score may have been interpreted by individual pharmacists, and so there may be a potential lack of consistency. Nevertheless, this was a pragmatic instrument, allowing a measure of self-reported efficacy to be established. We observed a relatively low number of pharmacies participating, which supports the idea that new work practices often take time to imbed within practice.27 It may also indicate that pharmacies may not yet have reconfigured levels of support or organizational infrastructure to comfortably undertake such services outside their pharmacies.

Looking more closely at ethnicity, the results suggest most of the patients who received a dMUR were of White British (89.2%) ethnicity. This could be a potential limitation of the service, that patients from underserved communities, eg, those from Black, Asian, and Minority Ethnic (BAME) communities, may not have been offered the service. An alternative explanation could be that this was simply due to the collection of data from rural areas (where the proportion of BAME patients is lower) compared to inner city areas. Another limitation was that the pilot study did not seek to collect any comparison data with the usual MUR service that are delivered from pharmacies. Further research is, therefore, necessary to assess how more effective a dMUR was over a MUR at reducing medicine-related problems.

Although the findings from this study did not show any concerns around pharmacists visiting patient’s home, a review of lone working policies would need to address any safety concerns of delivering the service within the patient’s home environment.

Conclusion

DMURs reduced the pharmacists’ self-assessed risk of hospital admissions and readmissions and reduced medicine-related problems. Further evaluation and expansion of this pilot is required to determine its cost-effectiveness.

Table 2

Medicine-related outcomes from dMUR (n=1062)

Variable	Sample proportion	95% CI
Patient reported problems and concerns	322 (30.3%)	27.6–33.1
Reported side-effects	178 (16.8%)	14.6–19.0
Reported missed doses (non-adherence)	177 (16.7%)	14.5–18.9
Identification of discontinued medicines and their removal	307 (28.9%)	26.2–31.6
Other patient issues (all that apply)
Security (ie, controlled drugs and safe suggested)	6 (0.6%)	0.1–1.1
Stock piling medicines	156 (14.7%)	12.6–16.8
Expired medicines	139 (13.1%)	11.1–15.1
Other	109 (10.3%)	8.5–12.1

Abbreviation: dMUR, domiciliary Medicine Use Review.

Table 3

Pharmacists’ actions following dMUR (n=1062)

Variable	Sample proportion	95% CI
Pharmacists’ actions (all that apply)
Patient education	584(55.0%)	52.0–58.0
Review of support (delivery, etc.)	451(42.5%)	39.5–45.5
Review of compliance aid/introduction	249(23.4%)	20.9–25.9
Inhaler technique check	186(17.5%)	15.2–19.8
7 day scripts/28 day scripts	85(8.0%)	6.4–9.6
Change of dose form recommended	58(5.5%)	4.1–6.9
Large print labels	32(3.0%)	2.0–4.0
Easy open caps	18(1.7%)	0.9–2.5
Medicines chart MARR?	23(2.2%)	1.3–3.1
None required	272(25.6%)	23.0–28.2
Other	65(6.1%)	4.7–7.5
Additional service to the dMUR (all that apply)
Medicines Cabinet check	470(44.3%)	41.3–47.3
Medicines synchronization	214(20.2%)	17.8–22.6
NMS	10(0.9%)	0.3–1.5
Referrals
None necessary	804(75.7%)	73.1–78.3
GP	230(21.6%)	19.1–24.1
Social Care support	5(0.5%)	0.1–0.9
Hospital support service	3(0.3%)	−0.0–0.6
District Nursing team	3(0.3%)	−0.0–0.6
Other	17(1.6%)	0.9–2.4
Pharmacists’ assessment of prevented hospital admissions
1 = no likelihood of emergency hospital admission prevented	687(64.7%)	61.8–67.6
2 = possible prevention of emergency hospital admission	298(28.1%)	25.4–30.8
3 = likely to prevent an emergency hospital admission	77(7.2%)	5.7–8.8

Abbreviations: dMUR, domiciliary Medicine Use Review; NMS, new medicines service.