| Literature DB >> 29763806 |
Leili Jalili-Baleh1, Elaheh Babaei2, Shahin Abdpour3, Syed Nasir Abbas Bukhari4, Alireza Foroumadi5, Ali Ramazani3, Mohammad Sharifzadeh6, Mohammad Abdollahi1, Mehdi Khoobi7.
Abstract
Alzheimer's disease (AD), the most common form of dementia, is a multifactorial neurodegenerative disease. The target enzymes inhibition including cholinesterase, beta-secretase, monoamine oxidase and inhibition of amyloid-β aggregation as well as oxidative stress and metal chelation play an important role in the pathogenesis of AD. Chroman-4-one scaffold with benzo-γ-pyrone network is a privileged structure in organic synthesis and drug design. A large number of research has been carried out on modified naturally occurring chromanone scaffolds and/or synthesized new analogues, to obtain effective drugs for AD management. The present review summarizes aspects related to the multi-target-directed ligands (MTDLs) strategy in enzyme targets modulation performed with natural and synthesized chroman-4-one-based structures to look at their potential in the management of multifactorial Alzheimer's disease.Entities:
Keywords: Amyloid-β; Beta-secretase; Cholinesterase; Chromanone; Monoamine oxidase; Multi-target drug ligands (MTDLs)
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Year: 2018 PMID： 29763806 DOI： 10.1016/j.ejmech.2018.05.004
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514