Eliza Grylls1, Max Kinsky2, Amy Baggott3, Cecile Wabnitz4, Ailsa McLellan5. 1. The University of Edinburgh, Edinburgh, Scotland, EH8 9YL, UK. Electronic address: eliza.grylls@nhs.net. 2. The University of Edinburgh, Edinburgh, Scotland, EH8 9YL, UK. Electronic address: Maximilian.Kinsky@auva.at. 3. The University of Edinburgh, Edinburgh, Scotland, EH8 9YL, UK. Electronic address: amy.baggott@nhs.net. 4. The University of Edinburgh, Edinburgh, Scotland, EH8 9YL, UK. Electronic address: c.wabnitz@nhs.net. 5. Department of Paediatric Neurosciences, Royal Hospital for Sick Children, Edinburgh, Scotland, EH9 1LF, UK. Electronic address: Ailsa.McLellan@nhslothian.scot.nhs.uk.
Abstract
PURPOSE: To establish if listening to Mozart's Sonata for two pianos in D major (K448) has an anti-epileptic effect on the EEGs (electroencephalograms) of children. METHODS: Forty five children (2-18 years; mean 7 years 10 months) who had epileptiform activity on EEG were recruited from those attending for scheduled EEG investigations. Mozart's Sonata for two pianos in D major (K448) and an age-appropriate control music were played during the EEG. There were five consecutive states during the record, each lasting 5 min; before Mozart music (baseline), during Mozart music, after Mozart music/before control music, during control music and after control music. Epileptic discharges were counted manually and the mean frequency of epileptic discharges calculated in each state. RESULTS: A significant reduction (p < 0.0005) in the frequency of epileptic discharges was found during listening to the Mozart music compared to the baseline. No evidence of a difference in mean epileptic discharges was found between the baseline and the other three states or between listening to the Mozart music and control music. CONCLUSION: This study confirms an anti-epileptic effect of Mozart music on the EEG in children, which is not present with control music. The role of 'Mozart therapy' as a treatment for drug-resistant epilepsy warrants further investigation.
PURPOSE: To establish if listening to Mozart's Sonata for two pianos in D major (K448) has an anti-epileptic effect on the EEGs (electroencephalograms) of children. METHODS: Forty five children (2-18 years; mean 7 years 10 months) who had epileptiform activity on EEG were recruited from those attending for scheduled EEG investigations. Mozart's Sonata for two pianos in D major (K448) and an age-appropriate control music were played during the EEG. There were five consecutive states during the record, each lasting 5 min; before Mozart music (baseline), during Mozart music, after Mozart music/before control music, during control music and after control music. Epileptic discharges were counted manually and the mean frequency of epileptic discharges calculated in each state. RESULTS: A significant reduction (p < 0.0005) in the frequency of epileptic discharges was found during listening to the Mozart music compared to the baseline. No evidence of a difference in mean epileptic discharges was found between the baseline and the other three states or between listening to the Mozart music and control music. CONCLUSION: This study confirms an anti-epileptic effect of Mozart music on the EEG in children, which is not present with control music. The role of 'Mozart therapy' as a treatment for drug-resistant epilepsy warrants further investigation.
Authors: Robert J Quon; Grace A Leslie; Edward J Camp; Stephen Meisenhelter; Sarah A Steimel; Yinchen Song; Alan B Ettinger; Krzysztof A Bujarski; Michael A Casey; Barbara C Jobst Journal: Acta Neurol Scand Date: 2021-04-24 Impact factor: 3.915
Authors: Robert J Quon; Michael A Casey; Edward J Camp; Stephen Meisenhelter; Sarah A Steimel; Yinchen Song; Markus E Testorf; Grace A Leslie; Krzysztof A Bujarski; Alan B Ettinger; Barbara C Jobst Journal: Sci Rep Date: 2021-09-16 Impact factor: 4.379