Dong Hoon Lee1, Sun Hwa Lee2, Je Hyeok Oh3, In Soo Cho4, Young Hwan Lee5, Chul Han6, Wook Jin Choi7, You Dong Sohn8. 1. Department of Emergency Medicine, Chung-Ang University Hospital, College of Medicine, 102, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea. Electronic address: emdhlee@cau.ac.kr. 2. Department of Emergency Medicine, Sanggye paik Hospital, Inje University, Dongil-ro 1342, Nowon-gu, Seoul, Republic of Korea. Electronic address: sunhwa9@hanmail.net. 3. Department of Emergency Medicine, Chung-Ang University Hospital, College of Medicine, 102, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea. Electronic address: jehyeokoh@cau.ac.kr. 4. Department of Emergency Medicine, Hanil General Hospital, 308, Uicheon-ro, Dobong-gu, Seoul, Republic of Korea. Electronic address: mensa@hanmail.net. 5. Department of Emergency Medicine, Soonchunhyang University Bucheon Hospital, 170 jomaru-ro, Wonmi-gu, Bucheon, Gyenggi-do, Republic of Korea. Electronic address: hwaniyo@naver.com. 6. Emergency Medicine, Ewha Womans University Medical Center, 1071, Anyangcheon-ro, Yangcheon-gu, Seoul, Republic of Korea. Electronic address: achwow@ewha.ac.kr. 7. Department of Emergency Medicine, University of Ulsan College of Medicine, Ulsan University Hospital, 877, Bangeojinsunhwando-ro, Dong-gu, Ulsan, Republic of Korea. Electronic address: koreanermd@gmail.com. 8. Department of Emergency Medicine, Hallym University Sacred Heart Hospital, 22, Gwanpyeong-ro 170 beon-gil, Dongan-gu, Anyang-si, Gyeonggi-do, Republic of Korea; Department of Emergency Medicine, Seoul National University, College of Medicine, Seoul National University Boramae Medical Center, Seoul, Republic of Korea. Electronic address: medysohn@gmail.com.
Abstract
AIM: Previous studies indicated that the optic nerve sheath diameter (ONSD) measured using brain computed tomography (CT) is a prognostic factor for poor neurological outcome after cardiac arrest. However, these studies were retrospective or included a small sample size. We performed a prospective multi-centre observational study to investigate the correlation between the ONSD on early brain CT and neurological outcomes in patients undergoing targeted temperature management (TTM). METHODS: This study used data from the Korean Hypothermia Network prospective registry between November 2015 and October 2016. Out-of-cardiac arrest patients who underwent brain CT within 2 h after return of spontaneous circulation (ROSC) were included. The primary endpoint was neurological outcomes at 6 months (cerebral performance category; CPC); the secondary outcome was hospital mortality. The ONSD was measured using unenhanced brain CT images. RESULTS: In total, 374 patients were included from 18 hospitals, and 329 underwent CT within 2 h after ROSC. Six months after cardiac arrest, good (CPC 1-2) and poor (CPC 3-5) neurological outcomes were observed in 99 (30.09%) and 230 (69.91%) patients, respectively. There was no significant difference in the ONSD between groups (good outcome group: 5.61 ± 0.59 mm, poor outcome group: 5.69 ± 0.79 mm; p = 0.275), nor between discharged patients who survived and those with hospital mortality (5.63 ± 0.64 mm and 5.70 ± 0.67 mm, respectively, p = 0.399). CONCLUSION: The ONSD on initial brain CT after ROSC was not correlated with neurological outcome at 6 months in patients who underwent TTM.
AIM: Previous studies indicated that the optic nerve sheath diameter (ONSD) measured using brain computed tomography (CT) is a prognostic factor for poor neurological outcome after cardiac arrest. However, these studies were retrospective or included a small sample size. We performed a prospective multi-centre observational study to investigate the correlation between the ONSD on early brain CT and neurological outcomes in patients undergoing targeted temperature management (TTM). METHODS: This study used data from the Korean Hypothermia Network prospective registry between November 2015 and October 2016. Out-of-cardiac arrestpatients who underwent brain CT within 2 h after return of spontaneous circulation (ROSC) were included. The primary endpoint was neurological outcomes at 6 months (cerebral performance category; CPC); the secondary outcome was hospital mortality. The ONSD was measured using unenhanced brain CT images. RESULTS: In total, 374 patients were included from 18 hospitals, and 329 underwent CT within 2 h after ROSC. Six months after cardiac arrest, good (CPC 1-2) and poor (CPC 3-5) neurological outcomes were observed in 99 (30.09%) and 230 (69.91%) patients, respectively. There was no significant difference in the ONSD between groups (good outcome group: 5.61 ± 0.59 mm, poor outcome group: 5.69 ± 0.79 mm; p = 0.275), nor between discharged patients who survived and those with hospital mortality (5.63 ± 0.64 mm and 5.70 ± 0.67 mm, respectively, p = 0.399). CONCLUSION: The ONSD on initial brain CT after ROSC was not correlated with neurological outcome at 6 months in patients who underwent TTM.
Authors: Sung Ho Kwon; Sang Hoon Oh; Jinhee Jang; Soo Hyun Kim; Kyu Nam Park; Chun Song Youn; Han Joon Kim; Jee Yong Lim; Hyo Joon Kim; Hyo Jin Bang Journal: J Clin Med Date: 2022-06-26 Impact factor: 4.964
Authors: Heekyung Lee; Joonkee Lee; Hyungoo Shin; Changsun Kim; Hyuk-Joong Choi; Bo-Seung Kang Journal: Int J Environ Res Public Health Date: 2021-06-18 Impact factor: 3.390