Literature DB >> 29763

An interaction of histamine H2-receptor antagonists with the noradrenergic system in rat brain.

J Z Nowak, A Pilc, C Maśliński.   

Abstract

Intraventricular administration of 50 microgram of burimamide or 250 microgram of either metiamide or cimetidine decreased the NA concentration in rat hypothalamus by nearly 30%. Cimetidine did not significantly influence either DA or DOPAC levels in striatum. Cimetidine and metiamide significantly potentiated locomotor activity of tranylcypromine-treated rats and this effect was antagonized by phentolamine. It is concluded that the three histamine H2-receptor antagonists released NA in rat brain.

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Year:  1978        PMID： 29763     DOI： 10.1016/0014-2999(78)90063-8

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  4 in total

1.  Differences in presynaptic alpha-blockade, noradrenaline uptake inhibition, and potential antidepressant activity between (+)- and (-)mianserin.

Authors:  H Schoemaker; H H Berendsen; H J Stevens; V J Nickolson
Journal:  Psychopharmacology (Berl)       Date:  1981       Impact factor: 4.530

2.  Effects of the histamine H2-receptor agonists dimaprit and 4-methylhistamine on the central noradrenaline and serotonin system.

Authors:  J Z Nowak; B Bielkiewicz; U Lebrecht; A Kordecka; C Maslinski
Journal:  Agents Actions       Date:  1980-04

3.  Central effects of histamine H2-receptor agonists and antagonists on nociception in the rat.

Authors:  C Netti; F Guidobono; V Sibilia; I Villa; E Cazzamalli; A Pecile
Journal:  Agents Actions       Date:  1988-04

4.  Influence of the H2-receptor blocking agent metiamide on the clonidine-induced changes in the brain catecholamine turnover.

Authors:  N E Andén; M Grabowska-Andén
Journal:  J Neural Transm       Date:  1980       Impact factor: 3.575
  4 in total

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