Cheng Wei1, Magdalena Szewczyk-Bieda2, Paddy Nibblok3, E Brown4, Stephen Lang3, Ghulam Nabi5. 1. Academic Section of Urology, Division of Cancer Research, School of Medicine, University of Dundee, Dundee, Scotland, UK. 2. Department of Radiology, Ninewells Hospital, NHS Tayside, University of Dundee, Dundee, Scotland, UK. 3. Department of Pathology, Ninewells Hospital, NHS Tayside, University of Dundee, Dundee, Scotland, UK. 4. Department of Radiation Oncology, Ninewells Hospital, NHS Tayside, University of Dundee, Dundee, Scotland, UK. 5. Academic Section of Urology, Division of Cancer Research, School of Medicine, University of Dundee, Dundee, Scotland, UK. g.nabi@dundee.ac.uk.
Abstract
BACKGROUND: To evaluate pre-surgical quantitative transrectal shear wave elastography (SWE) in the detection and characterisation of radioresistant prostate cancer. METHODS: Twelve men with recurrent prostate cancer following external beam radiotherapy were included in a prospective protocol-driven study. All underwent MR imaging and quantitative shear wave elastographic assessment of recurrent disease prior to salvage laparoscopic radical prostatectomy procedures. Images were used to construct 3D mold printing and histopathological processing of surgical specimen. Statistical analyses including ROC were generated using software programmes. RESULTS: There were 48 cancer foci identified on final histopathology using patient-specific mold-based approach in 12 patients. Mean number of lesion was 3.4 (range 2-4). Quantitative transrectal SWE showed a sensitivity and specificity 0.77 (95% CI 0.627-0.880) and 0.82 (95% CI 0.642-0.942), respectively. The diagnostic accuracy increased with increasing size of the lesions with overall AUC of 0.89. CONCLUSIONS: In our series, quantitative transrectal SWE showed a good diagnostic accuracy in the detection and characterisation of recurrent prostate cancer following failed radiotherapy treatment. These findings may help in targeting biopsies or future focal treatment options.
BACKGROUND: To evaluate pre-surgical quantitative transrectal shear wave elastography (SWE) in the detection and characterisation of radioresistant prostate cancer. METHODS: Twelve men with recurrent prostate cancer following external beam radiotherapy were included in a prospective protocol-driven study. All underwent MR imaging and quantitative shear wave elastographic assessment of recurrent disease prior to salvage laparoscopic radical prostatectomy procedures. Images were used to construct 3D mold printing and histopathological processing of surgical specimen. Statistical analyses including ROC were generated using software programmes. RESULTS: There were 48 cancer foci identified on final histopathology using patient-specific mold-based approach in 12 patients. Mean number of lesion was 3.4 (range 2-4). Quantitative transrectal SWE showed a sensitivity and specificity 0.77 (95% CI 0.627-0.880) and 0.82 (95% CI 0.642-0.942), respectively. The diagnostic accuracy increased with increasing size of the lesions with overall AUC of 0.89. CONCLUSIONS: In our series, quantitative transrectal SWE showed a good diagnostic accuracy in the detection and characterisation of recurrent prostate cancer following failed radiotherapy treatment. These findings may help in targeting biopsies or future focal treatment options.
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