| Literature DB >> 2976059 |
M W Oberle1, L Rosero-Bixby, K L Irwin, J A Fortney, N C Lee, A S Whatley, M G Bonhomme.
Abstract
The relationship between cervical cancer and the use of depot-medroxyprogesterone acetate (DMPA) was examined in a nationwide case-control study in Costa Rica. Cases were women ages 25-58 years of age with invasive squamous cell cancer (N = 149) or carcinoma in situ (CIS, N = 415) reported by the National Tumor Registry during 1982-84. Controls (N = 764) were randomly selected during a nationwide household survey. Using logistic regression, we adjusted for known risk factors for cervical cancer. DMPA use was associated with a risk of CIS of 1.1 (95% confidence interval 0.6-1.8) and a risk of invasive cancer of 1.4 (95% confidence interval 0.6-3.1). The slightly elevated risks observed may be the result of chance or a detection bias. One limitation of this study is that few women had used DMPA for longer than two years.Entities:
Keywords: Age Factors; Americas; Behavior; Cancer; Central America; Cervical Cancer; Comparative Studies; Contraception; Contraceptive Agents, Female--side effects; Contraceptive Agents, Progestin--side effects; Contraceptive Agents--side effects; Costa Rica; Demographic Factors; Developing Countries; Diseases; Economic Factors; Family Planning; Infections; Latin America; Medroxyprogesterone Acetate--side effects; Neoplasms; North America; Pelvic Infections; Population; Population Characteristics; Reproductive Tract Infections; Research Methodology; Sex Behavior; Sexually Transmitted Diseases; Socioeconomic Factors; Socioeconomic Status; Studies
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Year: 1988 PMID： 2976059 DOI： 10.1093/ije/17.4.718
Source DB: PubMed Journal: Int J Epidemiol ISSN： 0300-5771 Impact factor: 7.196