Literature DB >> 29760139

ClpA and HtpX Proteases Are Involved in Intrinsic Aminoglycoside Resistance of Stenotrophomonas maltophilia and Are Potential Aminoglycoside Adjuvant Targets.

Hsin-Hui Huang1, Yi-Tsung Lin2,3, Peng-Ying Chen1, Li-Hua Li4,5, Hsiao-Chen Ning6,7, Tsuey-Ching Yang8.   

Abstract

The linkage of the protease-chaperon system, SmeYZ pump, and aminoglycoside resistance was assessed in Stenotrophomonas maltophilia The clpA, clpS, clpP, and htpX genes were upregulated in response to kanamycin exposure. Of these, clpA and htpX were the primary determinants responsible for intrinsic aminoglycoside (AG) resistance. Inactivation of clpA and htpX compromised protease-mediated intrinsic aminoglycoside resistance and weakened SmeYZ pump-mediated aminoglycoside resistance, signifying HtpX and ClpA as potential AG adjuvant targets for treatment of S. maltophilia infections.
Copyright © 2018 American Society for Microbiology.

Entities:  

Keywords:  Stenotrophomonas maltophilia; aminoglycoside resistance; chaperone; protease

Mesh：

Substances：

Year:  2018        PMID： 29760139      PMCID： PMC6105848          DOI： 10.1128/AAC.00554-18

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  17 in total

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Authors:  Janine T Lin; Mariah Bindel Connelly; Chris Amolo; Suzie Otani; Debbie S Yaver
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8.  Proteolytic activity of HtpX, a membrane-bound and stress-controlled protease from Escherichia coli.

Authors:  Machiko Sakoh; Koreaki Ito; Yoshinori Akiyama
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9.  Structural basis for aminoglycoside inhibition of bacterial ribosome recycling.

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Review 10.  Antibiotic resistance in the opportunistic pathogen Stenotrophomonas maltophilia.

Authors:  María B Sánchez
Journal:  Front Microbiol       Date:  2015-06-30       Impact factor: 5.640
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3.  Mutations in Ribosomal Protein RplA or Treatment with Ribosomal Acting Antibiotics Activates Production of Aminoglycoside Efflux Pump SmeYZ in Stenotrophomonas maltophilia.

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Journal:  Nat Commun       Date:  2020-04-27       Impact factor: 14.919

6.  Advances in the Microbiology of Stenotrophomonas maltophilia.

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  6 in total

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