Stefano Fumagalli1, Salah A M Said2, Cecile Laroche3, Debbie Gabbai4, Niccolò Marchionni4, Giuseppe Boriani5, Aldo P Maggioni3, Mircea Ioachim Popescu6, Lars Hvilsted Rasmussen7, Harry J G M Crijns8, Gregory Y H Lip9. 1. Division of Geriatric Cardiology and Medicine, Department of Experimental and Clinical Medicine, University of Florence and AOU Careggi, Florence, Italy. Electronic address: fumadue@tin.it. 2. Department of Cardiology, Hospital Group Twente, Almelo-Hengelo, Hengelo, the Netherlands. 3. EURObservational Research Programme Department, European Society of Cardiology, Sophia Antipolis, France. 4. Division of Geriatric Cardiology and Medicine, Department of Experimental and Clinical Medicine, University of Florence and AOU Careggi, Florence, Italy. 5. Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, S. Orsola Malpighi University Hospital, Bologna, Italy. 6. County Emergency Hospital, Oradea, Romania. 7. Aalborg University Hospital, Aalborg, Denmark. 8. Department of Cardiology, Maastricht University Medical Center, Maastricht, the Netherlands. 9. University of Birmingham, Center for Cardiovascular Sciences, City Hospital, Birmingham, United Kingdom.
Abstract
OBJECTIVES: This study sought to compare age-related differences in presentation, treatment, and outcome of atrial fibrillation (AF) in a wide cohort of European subjects. BACKGROUND: AF is the most common sustained arrhythmia in the elderly. METHODS: We evaluated all patients enrolled in the EORP-AF (EURObservational Research Programme-Atrial Fibrillation) General Pilot Registry in 70 centers of 9 European countries. RESULTS: Among 3,119 subjects, 1,051 (33.7%) were age ≥75 years. Permanent AF was significantly more common in the elderly, who had a higher prevalence of hypertension, valvular diseases, chronic heart failure, coronary artery disease, renal failure, chronic obstructive pulmonary disease, and prior hemorrhagic event or a transient ischemic attack. Common diagnostic tests were underused in older subjects. Despite their higher stroke risk, the use of oral anticoagulants was significantly lower in the elderly (76.7% vs. 82.8%; p = 0.0012), whereas aspirin and clopidogrel alone or in combination were more often prescribed. Rate control was the management of choice in the older group, with electrical cardioversion and catheter ablation performed less frequently than in the younger age group. Antiarrhythmic drugs were significantly less prescribed in the elderly (29.8% vs. 41.7%; p < 0.0001). At the 1-year follow-up, mortality (11.5% vs. 3.7%; p < 0.0001) and the composite of stroke/transient ischemic attack, systemic thromboembolism, and/or death (13.6% vs. 4.9%; p < 0.0001) were significantly higher in the ≥75 years of age cohort. CONCLUSIONS: In older patients, AF is more often associated with comorbidities. Rate control is the preferred therapeutic approach. Despite a higher CHA2DS2-VASc score, the use of oral anticoagulation is suboptimal. In elderly subjects, the rate of adverse events is higher at follow-up.
OBJECTIVES: This study sought to compare age-related differences in presentation, treatment, and outcome of atrial fibrillation (AF) in a wide cohort of European subjects. BACKGROUND:AF is the most common sustained arrhythmia in the elderly. METHODS: We evaluated all patients enrolled in the EORP-AF (EURObservational Research Programme-Atrial Fibrillation) General Pilot Registry in 70 centers of 9 European countries. RESULTS: Among 3,119 subjects, 1,051 (33.7%) were age ≥75 years. Permanent AF was significantly more common in the elderly, who had a higher prevalence of hypertension, valvular diseases, chronic heart failure, coronary artery disease, renal failure, chronic obstructive pulmonary disease, and prior hemorrhagic event or a transient ischemic attack. Common diagnostic tests were underused in older subjects. Despite their higher stroke risk, the use of oral anticoagulants was significantly lower in the elderly (76.7% vs. 82.8%; p = 0.0012), whereas aspirin and clopidogrel alone or in combination were more often prescribed. Rate control was the management of choice in the older group, with electrical cardioversion and catheter ablation performed less frequently than in the younger age group. Antiarrhythmic drugs were significantly less prescribed in the elderly (29.8% vs. 41.7%; p < 0.0001). At the 1-year follow-up, mortality (11.5% vs. 3.7%; p < 0.0001) and the composite of stroke/transient ischemic attack, systemic thromboembolism, and/or death (13.6% vs. 4.9%; p < 0.0001) were significantly higher in the ≥75 years of age cohort. CONCLUSIONS: In older patients, AF is more often associated with comorbidities. Rate control is the preferred therapeutic approach. Despite a higher CHA2DS2-VASc score, the use of oral anticoagulation is suboptimal. In elderly subjects, the rate of adverse events is higher at follow-up.
Authors: Gregory Y H Lip; Giuseppe Boriani; Vincenzo L Malavasi; Marco Vitolo; Jacopo Colella; Francesca Montagnolo; Marta Mantovani; Marco Proietti; Tatjana S Potpara Journal: Intern Emerg Med Date: 2021-12-02 Impact factor: 5.472
Authors: Thomas M Roston; Sunjidatul Islam; Nathaniel M Hawkins; Zachary W Laksman; Shubhayan Sanatani; Andrew D Krahn; Roopinder Sandhu; Padma Kaul Journal: CJC Open Date: 2021-09-14
Authors: Christian Waechter; Felix Ausbuettel; Georgios Chatzis; Dieter Fischer; Holger Nef; Sebastian Barth; Philipp Halbfaß; Thomas Deneke; Sebastian Kerber; Dimitar Divchev; Bernhard Schieffer; Ulrich Luesebrink Journal: J Interv Cardiol Date: 2020-08-28 Impact factor: 2.279