| Literature DB >> 29759126 |
Abstract
Polymyalgia rheumatica (PMR) and giant cell arteritis (GCA) are related inflammatory diseases of adults aged 50 years or older. The diagnosis of PMR is based on morning stiffness, proximal shoulder and pelvic girdle pain, and functional impairment. GCA is characterized by headache, jaw claudication, and visual disturbances. Constitutional symptoms and elevated inflammatory markers are common to both conditions. Temporal artery biopsy remains the gold standard for diagnosis of GCA. Glucocorticoids are the cornerstone of therapy, with tapering regimens individualized to the patient. Prompt diagnosis and treatment are essential to avert vision loss in GCA. Tocilizumab increases remission rates in GCA.Entities:
Keywords: Corticosteroids; Giant cell arteritis; Polymyalgia rheumatica; Temporal artery biopsy; Tocilizumab
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Year: 2018 PMID: 29759126 DOI: 10.1016/j.pop.2018.02.007
Source DB: PubMed Journal: Prim Care ISSN: 0095-4543 Impact factor: 2.907