| Literature DB >> 29757551 |
Yong Yan Wu1, Wei Gao1, Yu Liang Zhang1, Min Niu1, Jia Jia Cui1, Cai Xia Xiang1, Jiang Wei Sang1, Shu Xin Wen1, Bin Quan Wang1.
Abstract
Objective:To investigate the expression of LINC00520 in laryngeal squamous cell carcinoma(LSCC),and analyze its relevance and roles in carcinogenesis and development of LSCC.Method:The expression of LINC00520 in laryngeal squamous cell carcinoma tissue and paired adjacent normal tissue was determined by real-time PCR.The relationship between the expression of LINC00520 and the clinicopathological characteristics including clinical stage,pathological type,histological grade and lymph node metastasis of LSCC was analyzed.Result:(1)The LINC00520 expression level was significantly upregulated in LSCC tissues compared to that of paired adjacent normal tissues(P<0.000 1).(2)There were no statistical differences of the LINC00520 expression level among supraglottic,glottic and subglottic LSCCs(P>0.05).The LINC00520 expression level had no significant changes in poorly differentiated LSCC compared with that of well and moderately differentiated counterparts(P>0.05).Moreover,the expression of LINC00520 had no significant difference between T1+T2 stage and T3+T4 stage LSCC tissues(P>0.05).Interestingly,the LINC00520 level in LSCC with lymph node metastasis was significantly higher than that in patients without lymph node metastasis(P<0.01).Entities:
Keywords: LINC00520; laryngeal neoplasms; long non-coding RNA; tumor metastasis
Mesh：
Substances：
Year: 2018 PMID： 29757551 DOI： 10.13201/j.issn.1001-1781.2018.02.003
Source DB: PubMed Journal: Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi ISSN： 1001-1781