Chengyong Yu1, Liyan Hou2, Hailing Cui1, Liyan Zhang1, Xiaodong Tan1, Xuejiao Leng1, Yingbo Li3. 1. Clinical Laboratory, Weihai Central Hospital, Weihai 264400, Shandong, PR China. 2. Department of Pharmacy, Weihai Central Hospital, Weihai 264400, Shandong, PR China. 3. Department of Blood Transfusion, Weihai Central Hospital, Weihai 264400, Shandong, PR China.
Abstract
AIM: To investigate the potential prognostic value of LDHA in lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC). PATIENTS & METHODS: Molecular, clinicopathological and survival data in Cancer Genome Atlas-Lung Cancer were obtained for secondary analysis. RESULTS: LDHA expression was significantly upregulated in both LUAD and LUSC compared with normal lung tissues. LUSC tissues had even higher LDHA expression compared with LUAD tissues. Increased LDHA expression was an independent prognostic indicator in terms of overall survival (hazard ratio: 1.547, 95% CI: 1.253-1.911; p < 0.001) and recurrence-free survival (hazard ratio: 1.486, 95% CI: 1.161-1.900; p = 0.002) in LUAD, but not in LUSC. CONCLUSION: LDHA expression might only serve as an independent prognostic indicator of unfavorable overall survival and recurrence-free survival in LUAD, but not in LUSC.
AIM: To investigate the potential prognostic value of LDHA in lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC). PATIENTS & METHODS: Molecular, clinicopathological and survival data in Cancer Genome Atlas-Lung Cancer were obtained for secondary analysis. RESULTS:LDHA expression was significantly upregulated in both LUAD and LUSC compared with normal lung tissues. LUSC tissues had even higher LDHA expression compared with LUAD tissues. Increased LDHA expression was an independent prognostic indicator in terms of overall survival (hazard ratio: 1.547, 95% CI: 1.253-1.911; p < 0.001) and recurrence-free survival (hazard ratio: 1.486, 95% CI: 1.161-1.900; p = 0.002) in LUAD, but not in LUSC. CONCLUSION:LDHA expression might only serve as an independent prognostic indicator of unfavorable overall survival and recurrence-free survival in LUAD, but not in LUSC.