Literature DB >> 29755777

Management of locally advanced rectal cancer in the elderly: a critical review and algorithm.

Lara Hathout1, Nell Maloney-Patel2, Usha Malhotra3, Shang-Jui Wang1, Sita Chokhavatia4, Ishita Dalal5, Elizabeth Poplin3, Salma K Jabbour1.   

Abstract

Colorectal cancer incidence and death rates have been declining over the past 10 years. However, it remains the second leading cause of death in men ages 60-79 and the third leading cause of death in men over 80 and in women over 60 years old. However, there is little data specific to the treatment of the elder patient, since few of these patients are included in trials. With the advent of improved therapies, there are many alternative options available. Still, no definitive consensus or guidelines have been defined for this particular patient population. The goal of this study is to review the literature on the management of rectal cancer in the elderly and to propose treatment algorithms to help the oncology team in treatment decision-making.

Entities:  

Keywords:  Rectal cancer; elderly; treatment algorithm

Year:  2018        PMID: 29755777      PMCID: PMC5934158          DOI: 10.21037/jgo.2017.10.10

Source DB:  PubMed          Journal:  J Gastrointest Oncol        ISSN: 2078-6891


  129 in total

1.  Predicting chemotherapy toxicity in older adults and the importance of geriatric assessment.

Authors:  Joep Lagro; Stephanie A Studenski; Marcel G M Olde Rikkert
Journal:  J Clin Oncol       Date:  2011-12-19       Impact factor: 44.544

2.  Elderly patients with rectal cancer have a higher risk of treatment-related complications and a poorer prognosis than younger patients: a population-based study.

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Journal:  Eur J Cancer       Date:  2006-06-22       Impact factor: 9.162

3.  Predicting chemotherapy toxicity in older adults with cancer: a prospective multicenter study.

Authors:  Arti Hurria; Kayo Togawa; Supriya G Mohile; Cynthia Owusu; Heidi D Klepin; Cary P Gross; Stuart M Lichtman; Ajeet Gajra; Smita Bhatia; Vani Katheria; Shira Klapper; Kurt Hansen; Rupal Ramani; Mark Lachs; F Lennie Wong; William P Tew
Journal:  J Clin Oncol       Date:  2011-08-01       Impact factor: 44.544

4.  Does rectal cancer height influence the oncological outcome?

Authors:  A Bhangu; S Rasheed; G Brown; D Tait; D Cunningham; P Tekkis
Journal:  Colorectal Dis       Date:  2014-10       Impact factor: 3.788

5.  Improving the Evidence Base for Treating Older Adults With Cancer: American Society of Clinical Oncology Statement.

Authors:  Arti Hurria; Laura A Levit; William Dale; Supriya G Mohile; Hyman B Muss; Louis Fehrenbacher; Allison Magnuson; Stuart M Lichtman; Suanna S Bruinooge; Enrique Soto-Perez-de-Celis; William P Tew; Michael A Postow; Harvey J Cohen
Journal:  J Clin Oncol       Date:  2015-07-20       Impact factor: 44.544

6.  Rectal cancer surgery in patients more than 80 years of age.

Authors:  Alain Barrier; Leonardo Ferro; Sidney Houry; François Lacaine; Michel Huguier
Journal:  Am J Surg       Date:  2003-01       Impact factor: 2.565

7.  A comparison of laparoscopically assisted and open colectomy for colon cancer.

Authors:  Heidi Nelson; Daniel J Sargent; H Sam Wieand; James Fleshman; Mehran Anvari; Steven J Stryker; Robert W Beart; Michael Hellinger; Richard Flanagan; Walter Peters; David Ota
Journal:  N Engl J Med       Date:  2004-05-13       Impact factor: 91.245

8.  Assessment of outcomes after colorectal cancer resection in the elderly as a rationale for screening and early detection.

Authors:  A J Clark; D Stockton; A Elder; R G Wilson; M G Dunlop
Journal:  Br J Surg       Date:  2004-10       Impact factor: 6.939

Review 9.  Local curative treatment of rectal cancer by radiotherapy alone.

Authors:  J P Gérard; P Romestaing; J Baulieux
Journal:  Colorectal Dis       Date:  2003-09       Impact factor: 3.788

10.  Surgery and pre-operative irradiation for locally advanced or recurrent rectal cancer in patients over 75 years of age.

Authors:  S G Larsen; J N Wiig; S Tretli; K-E Giercksky
Journal:  Colorectal Dis       Date:  2006-03       Impact factor: 3.788

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  11 in total

Review 1.  Locally Advanced Rectal Cancer: Treatment Approach in Elderly Patients.

Authors:  Francesca De Felice; Daniele Crocetti; Veronica Maiuri; Martina Parisi; Francesco Marampon; Luciano Izzo; Giorgio De Toma; Daniela Musio; Vincenzo Tombolini
Journal:  Curr Treat Options Oncol       Date:  2020-01-11

2.  Baseline anaemia increases locally advanced rectal cancer mortality in older patients undergoing preoperative chemoradiation.

Authors:  Darlene Rodrigues; Joana Simões; Laetitia Teixeira; Fátima Aires; Catarina Fernandes; Cármen Rey; Cristina Sarmento; Margarida Marques
Journal:  Support Care Cancer       Date:  2020-07-15       Impact factor: 3.603

3.  Inflammation-based prognostic scores in geriatric patients with rectal cancer.

Authors:  B Manoglu; S Sokmen; T Bisgin; H S Semiz; I B Görken; H Ellidokuz
Journal:  Tech Coloproctol       Date:  2022-10-05       Impact factor: 3.699

4.  Treatment Utilization and Outcomes for Locally Advanced Rectal Cancer in Older Patients.

Authors:  Sean Nassoiy; Wade Christopher; Rebecca Marcus; Jennifer Keller; Jessica Weiss; Shu-Ching Chang; Leland Foshag; Richard Essner; Trevan Fischer; Melanie Goldfarb
Journal:  JAMA Surg       Date:  2022-09-28       Impact factor: 16.681

5.  Toxicities and outcomes of neoadjuvant treatment in elderly patients with locally advanced rectal cancer: a scoping review protocol.

Authors:  Ruba Ahmed Hamed; Greg Korpanty; Dervla Kelly
Journal:  BMJ Open       Date:  2022-05-02       Impact factor: 3.006

Review 6.  Multidisciplinary management of elderly patients with rectal cancer: recommendations from the SICG (Italian Society of Geriatric Surgery), SIFIPAC (Italian Society of Surgical Pathophysiology), SICE (Italian Society of Endoscopic Surgery and new technologies), and the WSES (World Society of Emergency Surgery) International Consensus Project.

Authors:  Mauro Podda; Patricia Sylla; Gianluca Baiocchi; Michel Adamina; Vanni Agnoletti; Ferdinando Agresta; Luca Ansaloni; Alberto Arezzo; Nicola Avenia; Walter Biffl; Antonio Biondi; Simona Bui; Fabio C Campanile; Paolo Carcoforo; Claudia Commisso; Antonio Crucitti; Nicola De'Angelis; Gian Luigi De'Angelis; Massimo De Filippo; Belinda De Simone; Salomone Di Saverio; Giorgio Ercolani; Gustavo P Fraga; Francesco Gabrielli; Federica Gaiani; Mario Guerrieri; Angelo Guttadauro; Yoram Kluger; Ari K Leppaniemi; Andrea Loffredo; Tiziana Meschi; Ernest E Moore; Monica Ortenzi; Francesco Pata; Dario Parini; Adolfo Pisanu; Gilberto Poggioli; Andrea Polistena; Alessandro Puzziello; Fabio Rondelli; Massimo Sartelli; Neil Smart; Michael E Sugrue; Patricia Tejedor; Marco Vacante; Federico Coccolini; Justin Davies; Fausto Catena
Journal:  World J Emerg Surg       Date:  2021-07-02       Impact factor: 5.469

7.  Image-guided high-dose-rate brachytherapy for rectal cancer: technical note and first clinical experience on an organ-preserving approach.

Authors:  Maximilian Fleischmann; Markus Diefenhardt; Martin Trommel; Christian Scherf; Ulla Ramm; Georgios Chatzikonstantinou; Emmanouil Fokas; Claus Rödel; Nikolaos Tselis
Journal:  Strahlenther Onkol       Date:  2022-04-20       Impact factor: 4.033

8.  Rab23 contributes to the progression of colorectal cancer via protein kinase B and extracellular signal-regulated kinase signaling pathways.

Authors:  Tongbi Zhao; Dong Han; Huan Meng
Journal:  Oncol Lett       Date:  2019-06-18       Impact factor: 2.967

9.  Treatment response in elderly patients with advanced colorectal cancer at King Abdulaziz Medical City, Princess Norah Oncology Center, Jeddah.

Authors:  Abdullah Nasser Leslom; Fahad Juwayid Alqahtani; Abdulbari Ahmed Saeed Hanash; Abdullah Abdulhadi Alsubaie; Mohammed Saeed Alamri
Journal:  J Family Med Prim Care       Date:  2020-02-28

10.  Value of intra-tumor heterogeneity evaluated by diffusion-weighted MRI for predicting pathological stages and therapeutic responses to chemoradiotherapy in lower rectal cancer.

Authors:  Michihiro Kudou; Masayoshi Nakanishi; Yoshiaki Kuriu; Yasutoshi Murayama; Tomohiro Arita; Mitsuo Kishimoto; Eiichi Konishi; Mariko Goto; Kei Yamada; Eigo Otsuji
Journal:  J Cancer       Date:  2020-01-01       Impact factor: 4.207

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