Literature DB >> 29755142

THE LOCAL INFLUENCE OF PIONEER INVESTIGATORS ON TECHNOLOGY ADOPTION: EVIDENCE FROM NEW CANCER DRUGS.

Leila Agha1, David Molitor2.   

Abstract

Local opinion leaders may play a key role in easing information frictions associated with technology adoption. This paper analyzes the influence of physician investigators who lead clinical trials for new cancer drugs. By comparing diffusion patterns across 21 new cancer drugs, we separate correlated regional demand for new technology from information spillovers. Patients in the lead investigator's region are initially 36% more likely to receive the new drug, but utilization converges within four years. We also find that superstar physician authors, measured by trial role or citation history, have broader influence than less prominent authors.

Entities:  

Year:  2018        PMID: 29755142      PMCID: PMC5947964          DOI: 10.1162/REST_a_00670

Source DB:  PubMed          Journal:  Rev Econ Stat        ISSN: 0034-6535


  17 in total

1.  Externalities in hospitals and physician adoption of a new surgical technology: an exploratory analysis.

Authors:  J J Escarce
Journal:  J Health Econ       Date:  1996-12       Impact factor: 3.883

2.  Learning, Misallocation, and Technology Adoption: Evidence from New Malaria Therapy in Tanzania.

Authors:  Achyuta Adhvaryu
Journal:  Rev Econ Stud       Date:  2014

3.  Limits on Medicare's ability to control rising spending on cancer drugs.

Authors:  Peter B Bach
Journal:  N Engl J Med       Date:  2009-01-27       Impact factor: 91.245

4.  Regional variation in cancer-directed surgery and mortality among women with epithelial ovarian cancer in the Medicare population.

Authors:  Kathleen M Fairfield; F Lee Lucas; Craig C Earle; Laurie Small; Edward L Trimble; Joan L Warren
Journal:  Cancer       Date:  2010-10-15       Impact factor: 6.860

5.  Geographic variation in the use of breast-conserving treatment for breast cancer.

Authors:  A B Nattinger; M S Gottlieb; J Veum; D Yahnke; J S Goodwin
Journal:  N Engl J Med       Date:  1992-04-23       Impact factor: 91.245

6.  Geographic variation in the treatment of localized breast cancer.

Authors:  D C Farrow; W C Hunt; J M Samet
Journal:  N Engl J Med       Date:  1992-04-23       Impact factor: 91.245

7.  The implications of regional variations in Medicare spending. Part 1: the content, quality, and accessibility of care.

Authors:  Elliott S Fisher; David E Wennberg; Thérèse A Stukel; Daniel J Gottlieb; F L Lucas; Etoile L Pinder
Journal:  Ann Intern Med       Date:  2003-02-18       Impact factor: 25.391

8.  PRODUCTIVITY SPILLOVERS IN HEALTHCARE: EVIDENCE FROM THE TREATMENT OF HEART ATTACKS.

Authors:  Amitabh Chandra; Douglas O Staiger
Journal:  J Polit Econ       Date:  2007

9.  Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma.

Authors:  Gary Hudes; Michael Carducci; Piotr Tomczak; Janice Dutcher; Robert Figlin; Anil Kapoor; Elzbieta Staroslawska; Jeffrey Sosman; David McDermott; István Bodrogi; Zoran Kovacevic; Vladimir Lesovoy; Ingo G H Schmidt-Wolf; Olga Barbarash; Erhan Gokmen; Timothy O'Toole; Stephanie Lustgarten; Laurence Moore; Robert J Motzer
Journal:  N Engl J Med       Date:  2007-05-31       Impact factor: 91.245

10.  Nelarabine induces complete remissions in adults with relapsed or refractory T-lineage acute lymphoblastic leukemia or lymphoblastic lymphoma: Cancer and Leukemia Group B study 19801.

Authors:  Daniel J DeAngelo; Daohai Yu; Jeffrey L Johnson; Steven E Coutre; Richard M Stone; Alison T Stopeck; Jon P Gockerman; Beverly S Mitchell; Frederick R Appelbaum; Richard A Larson
Journal:  Blood       Date:  2007-03-07       Impact factor: 22.113

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  6 in total

1.  Association of Quetiapine Overuse Letters With Prescribing by Physician Peers of Targeted Recipients: A Secondary Analysis of a Randomized Clinical Trial.

Authors:  Adam Sacarny; Andrew R Olenski; Michael L Barnett
Journal:  JAMA Psychiatry       Date:  2019-10-01       Impact factor: 21.596

2.  Patient Characteristics Associated with Receipt of Prescription Weight-Management Medications Among Veterans Participating in MOVE!

Authors:  Dylan D Thomas; Molly E Waring; Omid Ameli; Joel I Reisman; Varsha G Vimalananda
Journal:  Obesity (Silver Spring)       Date:  2019-05-15       Impact factor: 5.002

3.  Drug Diffusion Through Peer Networks: The Influence of Industry Payments.

Authors:  Leila Agha; Dan Zeltzer
Journal:  Am Econ J Econ Policy       Date:  2022-05

4.  Dynamics of Health Technology Diffusion in the Integrated Care System (DHTDICS): A Development and Validation Study in China.

Authors:  Qingwen Deng; Junhong Lu; Zhichao Zeng; Yuhang Zheng; Wenbin Liu
Journal:  Risk Manag Healthc Policy       Date:  2021-01-27

5.  Surgeon and medical oncologist peer network effects on the uptake of the 21-gene breast cancer recurrence score assay.

Authors:  Ronnie Zipkin; Andrew Schaefer; Mary Chamberlin; Tracy Onega; Alistair J O'Malley; Erika L Moen
Journal:  Cancer Med       Date:  2021-01-16       Impact factor: 4.452

6.  Factors associated with immune checkpoint inhibitor use among older adults with late-stage melanoma: A population-based study.

Authors:  Pragya Rai; Chan Shen; Joanna Kolodney; Kimberly M Kelly; Virginia G Scott; Usha Sambamoorthi
Journal:  Medicine (Baltimore)       Date:  2021-02-19       Impact factor: 1.817

  6 in total

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