Juliana Pereira Borges1, Fernanda de Souza Nogueira Sardinha Mendes2, Gabriella de Oliveira Lopes3, Andréa Silvestre de Sousa2, Mauro Felippe Felix Mediano2, Eduardo Tibiriçá4. 1. Laboratory of Physical Activity and Health Promotion, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil. Electronic address: julipborges@gmail.com. 2. Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, RJ, Brazil. 3. Laboratory of Physical Activity and Health Promotion, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil; National Institute of Cardiology, Ministry of Health, Rio de Janeiro, RJ, Brazil. 4. National Institute of Cardiology, Ministry of Health, Rio de Janeiro, RJ, Brazil; Laboratory of Cardiovascular Investigation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, RJ, Brazil.
Abstract
BACKGROUND: Chronic Chagas cardiomyopathy (CCC) and cardiomyopathies due to other etiologies involve differences in pathophysiological pathways that are still unclear. Systemic microvascular abnormalities are associated with the pathogenesis of ischemic heart disease. However, systemic microvascular endothelial function in CCC remains to be elucidated. Thus, we compared the microvascular endothelial function of patients presenting with CCC to those with ischemic cardiomyopathy disease. METHODS: Microvascular reactivity was assessed in 21 patients with cardiomyopathy secondary to Chagas disease, 21 patients with cardiomyopathy secondary to ischemic disease and 21 healthy controls. Microvascular blood flow was assessed in the skin of the forearm using laser speckle contrast imaging coupled with iontophoresis of acetylcholine (ACh). RESULTS: Peak increase in forearm blood flow with ACh iontophoresis in relation to baseline was greater in healthy controls than in patients with heart disease (controls: 162.7 ± 58.4% vs. ischemic heart disease: 74.1 ± 48.3% and Chagas: 85.1 ± 68.1%; p < 0.0001). Patients with Chagas and ischemic cardiomyopathy presented similar ACh-induced changes from baseline in skin blood flow (p = 0.55). CONCLUSION: Endothelial microvascular function was equally impaired among patients with CCC and ischemic cardiomyopathy.
BACKGROUND: Chronic Chagas cardiomyopathy (CCC) and cardiomyopathies due to other etiologies involve differences in pathophysiological pathways that are still unclear. Systemic microvascular abnormalities are associated with the pathogenesis of ischemic heart disease. However, systemic microvascular endothelial function in CCC remains to be elucidated. Thus, we compared the microvascular endothelial function of patients presenting with CCC to those with ischemic cardiomyopathy disease. METHODS: Microvascular reactivity was assessed in 21 patients with cardiomyopathy secondary to Chagas disease, 21 patients with cardiomyopathy secondary to ischemic disease and 21 healthy controls. Microvascular blood flow was assessed in the skin of the forearm using laser speckle contrast imaging coupled with iontophoresis of acetylcholine (ACh). RESULTS: Peak increase in forearm blood flow with ACh iontophoresis in relation to baseline was greater in healthy controls than in patients with heart disease (controls: 162.7 ± 58.4% vs. ischemic heart disease: 74.1 ± 48.3% and Chagas: 85.1 ± 68.1%; p < 0.0001). Patients with Chagas and ischemic cardiomyopathy presented similar ACh-induced changes from baseline in skin blood flow (p = 0.55). CONCLUSION: Endothelial microvascular function was equally impaired among patients with CCC and ischemic cardiomyopathy.
Authors: Antonia Pino-Marín; Germán José Medina-Rincón; Sebastian Gallo-Bernal; Alejandro Duran-Crane; Álvaro Ignacio Arango Duque; María Juliana Rodríguez; Ramón Medina-Mur; Frida T Manrique; Julian F Forero; Hector M Medina Journal: Pathogens Date: 2021-04-22
Authors: Rafael Brolio Pavão; Henrique Turin Moreira; Antonio Oswaldo Pintya; Jorge Luis Haddad; André Vannuchi Badran; Moysés de Oliveira Lima-Filho; Igor Matos Lago; João Reynaldo Abbud Chierice; André Schmidt; J Antonio Marin-Neto Journal: Rev Soc Bras Med Trop Date: 2021-11-12 Impact factor: 1.581