Yanchun Wang1, Daoyu Hu1, Hao Yu1, Yaqi Shen1, Hao Tang1, Ihab R Kamel2, Zhen Li3. 1. Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan, Hubei 430030, China. 2. Department of Radiology, Johns Hopkins Hospital, Johns Hopkins University, MD, USA, 21287. 3. Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan, Hubei 430030, China. Electronic address: zhenli@hust.edu.cn.
Abstract
RATIONALE AND OBJECTIVES: We aimed to determine the utility of various diffusion parameters obtained from monoexponential, biexponential, and stretched exponential diffusion-weighted imaging (DWI) models in differentiating tumor stage and grade of bladder cancer. MATERIALS AND METHODS: Forty-five patients with pathologically confirmed bladder cancer underwent multi-b-value DWI. An apparent diffusion coefficient (ADC) was calculated from DWI by using a monoexponential model. A true diffusion coefficient (D), perfusion-related pseudo-diffusion coefficient (D*), and perfusion fraction (f) were calculated from DWI by using a biexponential model. A water molecular diffusion heterogeneity index (α) and distributed diffusion coefficient (DDC) were calculated from DWI by using a stretched exponential model. All parameters were compared between different stages and grades by using the Mann-Whitney U test. Receiver operating characteristic and intrareader correlation coefficient analysis were used for statistical evaluations. RESULTS: ADC, D, f, and DDC values were significantly higher in the non-muscle-invasive vs muscle-invasive bladder cancers (P = .000, .000, .002, and .000, respectively) and in low-grade vs high-grade ones (P = .000, .000, .018, and .000, respectively). D* value was significantly lower in the low-grade bladder cancers compared to high-grade ones (P = .012). The areas under the receiver operating characteristic curve of ADC, D, and DDC values were 0.945, 0.912, and 0.946 in staging bladder cancers; 0.866, 0.862, and 0.856 in grading bladder cancers, respectively. CONCLUSION: Biexponential and stretched exponential DWI models may provide more parameters in staging and grading bladder cancers and show a slight difference between DDC and ADC values in staging bladder cancers. These two DWI models, as well as the monoexponential models, were very helpful in staging and grading bladder cancers.
RATIONALE AND OBJECTIVES: We aimed to determine the utility of various diffusion parameters obtained from monoexponential, biexponential, and stretched exponential diffusion-weighted imaging (DWI) models in differentiating tumor stage and grade of bladder cancer. MATERIALS AND METHODS: Forty-five patients with pathologically confirmed bladder cancer underwent multi-b-value DWI. An apparent diffusion coefficient (ADC) was calculated from DWI by using a monoexponential model. A true diffusion coefficient (D), perfusion-related pseudo-diffusion coefficient (D*), and perfusion fraction (f) were calculated from DWI by using a biexponential model. A water molecular diffusion heterogeneity index (α) and distributed diffusion coefficient (DDC) were calculated from DWI by using a stretched exponential model. All parameters were compared between different stages and grades by using the Mann-Whitney U test. Receiver operating characteristic and intrareader correlation coefficient analysis were used for statistical evaluations. RESULTS: ADC, D, f, and DDC values were significantly higher in the non-muscle-invasive vs muscle-invasive bladder cancers (P = .000, .000, .002, and .000, respectively) and in low-grade vs high-grade ones (P = .000, .000, .018, and .000, respectively). D* value was significantly lower in the low-grade bladder cancers compared to high-grade ones (P = .012). The areas under the receiver operating characteristic curve of ADC, D, and DDC values were 0.945, 0.912, and 0.946 in staging bladder cancers; 0.866, 0.862, and 0.856 in grading bladder cancers, respectively. CONCLUSION: Biexponential and stretched exponential DWI models may provide more parameters in staging and grading bladder cancers and show a slight difference between DDC and ADC values in staging bladder cancers. These two DWI models, as well as the monoexponential models, were very helpful in staging and grading bladder cancers.
Authors: Xiaopan Xu; Huanjun Wang; Yan Guo; Xi Zhang; Baojuan Li; Peng Du; Yang Liu; Hongbing Lu Journal: Front Oncol Date: 2021-07-15 Impact factor: 6.244