Literature DB >> 29753015

LncRNA ZEB2-AS1 promotes pancreatic cancer cell growth and invasion through regulating the miR-204/HMGB1 axis.

Hai Gao1, Nana Gong2, Zebin Ma3, Xiaobo Miao4, Jinchun Chen5, Yan Cao6, Gong Zhang7.   

Abstract

Recently, lncRNA ZEB2-AS1 was identified as a lncRNA that promoted cancer progression. However, the biological function and the underlying mechanism of ZEB2-AS1 in pancreatic cancer had not been reported. In the current study, we revealed that the expression level of ZEB2-AS1 was elevated in pancreatic cancer cell lines and tissues. ZEB2-AS1 inhibition decreased cell growth and invasion in pancreatic cancer. Mechanismly, ZEB2-AS1 exerted as a ceRNA and negatively regulated miR-204 expression. In addition, HMGB1 was identified as a down-stream target of miR-204. The miR-204/HMGB1 axis mediated ZEB2-AS1's effect on pancreatic cancer. Our findings revealed that lncRNA ZEB2-AS1 may be a candidate prognostic biomarker and a target for new therapies in pancreatic cancer patients.
Copyright © 2018. Published by Elsevier B.V.

Entities:  

Keywords:  HMGB1; LncRNA ZEB2-AS1; Pancreatic cancer; miR-204

Mesh：

Substances：

Year:  2018        PMID： 29753015     DOI： 10.1016/j.ijbiomac.2018.05.044

Source DB:  PubMed          Journal:  Int J Biol Macromol        ISSN： 0141-8130            Impact factor:   6.953


  32 in total

1.  Long non-coding RNA ZEB2-AS1 regulates osteosarcoma progression by acting as a molecular sponge of miR-107 to modulate SALL4 expression.

Authors:  Yu Wang; Ning Liu; Ming-Yue Li; Mao-Fang Du
Journal:  Am J Transl Res       Date:  2021-03-15       Impact factor: 4.060

2.  The role of lncRNA MSC-AS1/miR-29b-3p axis-mediated CDK14 modulation in pancreatic cancer proliferation and Gemcitabine-induced apoptosis.

Authors:  Yunpeng Sun; Pengfei Wang; Wenjun Yang; Yunfeng Shan; Qiyu Zhang; Huanhuan Wu
Journal:  Cancer Biol Ther       Date:  2019-03-27       Impact factor: 4.742

3.  Circular RNA hsa_circ_0005909 modulates osteosarcoma progression via the miR-936/HMGB1 axis.

Authors:  Shuai Ding; Guangquan Zhang; Yanzheng Gao; Shulian Chen; Chen Cao
Journal:  Cancer Cell Int       Date:  2020-07-13       Impact factor: 5.722

4.  Long non-coding RNA ZEB2-AS1 promotes proliferation and inhibits apoptosis of colon cancer cells via miR-143/bcl-2 axis.

Authors:  Aihua Liu; Lihua Liu
Journal:  Am J Transl Res       Date:  2019-08-15       Impact factor: 4.060

Review 5.  The role of miRNAs in polycystic ovary syndrome with insulin resistance.

Authors:  Yingliu Luo; Chenchen Cui; Xiao Han; Qian Wang; Cuilian Zhang
Journal:  J Assist Reprod Genet       Date:  2021-01-06       Impact factor: 3.412

6.  Identification of LINC00665-miR-let-7b-CCNA2 competing endogenous RNA network associated with prognosis of lung adenocarcinoma.

Authors:  Yusheng Huang; Limei Zhong; Kechao Nie; Lijuan Li; Shaohua Song; Fengbin Liu; Peiwu Li; Donglin Cao; Yufeng Liu
Journal:  Sci Rep       Date:  2021-02-24       Impact factor: 4.379

7.  LncRNA FGD5-AS1 accelerates cell proliferation in pancreatic cancer by regulating miR-520a-3p/KIAA1522 axis.

Authors:  Jing Lin; Shasha Liao; Zewa Liu; E Li; Xiaohua Wu; Wanting Zeng
Journal:  Cancer Biol Ther       Date:  2021-04-02       Impact factor: 4.742

Review 8.  HMGB1 as a therapeutic target in disease.

Authors:  Jiaming Xue; Joelle S Suarez; Michael Minaai; Shuangjing Li; Giovanni Gaudino; Harvey I Pass; Michele Carbone; Haining Yang
Journal:  J Cell Physiol       Date:  2020-10-26       Impact factor: 6.384

Review 9.  Long noncoding RNAs: role and contribution in pancreatic cancer.

Authors:  K T Ramya Devi; Dharshene Karthik; TharunSelvam Mahendran; M K Jaganathan; Sanjana Prakash Hemdev
Journal:  Transcription       Date:  2021-05-26

10.  Pan-cancer characterization of long non-coding RNA and DNA methylation mediated transcriptional dysregulation.

Authors:  Zhen Yang; Feng Xu; Haizhou Wang; Andrew E Teschendorff; Feng Xie; Yungang He
Journal:  EBioMedicine       Date:  2021-05-24       Impact factor: 8.143
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