Feng Wu1, Hang Zhou2, Feng Li2, Jiang-Tao Wang2, Tao Ai3. 1. Radiology Department, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, No. 136 Jingzhou Street, Xiangyang 441021, HubeiChina. Electronic address: wf740214@sina.com. 2. Radiology Department, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, No. 136 Jingzhou Street, Xiangyang 441021, HubeiChina. 3. Radiology Department, Tongji Medical College of HuaZhong University of Science and Technology, Wuhan 430030, Hubei, China.
Abstract
RATIONALE AND OBJECTIVES: Spectral computed tomography (CT) imaging is widely used in the diagnosis of various cancers. This study aimed to analyze the characteristics of lung squamous cell carcinoma (SC) and adenocarcinoma (AC) using spectral CT imaging. METHODS: Sixty patients who were examined via spectral CT imaging and confirmed as having AC or SC via surgery and pathology were enrolled in this research project. A spectrum CT scanner was used, and both plain and enhanced CT scans were conducted to acquire spectral images. All patients' samples were used to detect the expression of thyroid transcription factor-1 (TTF-1) and epidermal growth factor receptor (EGFR) in cancer cells via immunohistochemical methods. RESULTS: Among the 27 cases with AC, 18 cases were identified as TTF-1 positive, 9 cases were found to be TTF-1 negative, 20 cases were confirmed as EGFR positive, and 7 cases were found to be EGFR negative. Among the 33 patients with SC, 6 cases were identified as TTF-1 positive, 27 cases were found to be TTF-1 negative, 19 cases were confirmed as EGFR positive, and 14 cases were found to be EGFR negative. No statistically significant differences were observed in normalized iodine concentration (NIC), K values, and calcium content between the TTF-1-positive and TTF-1-negative groups when considering patients. Statistically significant differences in NIC and K values were noted between the EGFR-positive and EGFR-negative groups among patients with AC, but no such difference was observed regarding calcium content. Significant differences in NIC, K values, and calcium content were observed between the EGFR-positive and EGFR-negative groups among patients with SC. CONCLUSIONS: In lung cancer cells, the parameters of spectral CT imaging, including NIC and K values, reflect the microvessel density and blood supply. Calcium content is an indicator of the growth status of lung SC.
RATIONALE AND OBJECTIVES: Spectral computed tomography (CT) imaging is widely used in the diagnosis of various cancers. This study aimed to analyze the characteristics of lung squamous cell carcinoma (SC) and adenocarcinoma (AC) using spectral CT imaging. METHODS: Sixty patients who were examined via spectral CT imaging and confirmed as having AC or SC via surgery and pathology were enrolled in this research project. A spectrum CT scanner was used, and both plain and enhanced CT scans were conducted to acquire spectral images. All patients' samples were used to detect the expression of thyroid transcription factor-1 (TTF-1) and epidermal growth factor receptor (EGFR) in cancer cells via immunohistochemical methods. RESULTS: Among the 27 cases with AC, 18 cases were identified as TTF-1 positive, 9 cases were found to be TTF-1 negative, 20 cases were confirmed as EGFR positive, and 7 cases were found to be EGFR negative. Among the 33 patients with SC, 6 cases were identified as TTF-1 positive, 27 cases were found to be TTF-1 negative, 19 cases were confirmed as EGFR positive, and 14 cases were found to be EGFR negative. No statistically significant differences were observed in normalized iodine concentration (NIC), K values, and calcium content between the TTF-1-positive and TTF-1-negative groups when considering patients. Statistically significant differences in NIC and K values were noted between the EGFR-positive and EGFR-negative groups among patients with AC, but no such difference was observed regarding calcium content. Significant differences in NIC, K values, and calcium content were observed between the EGFR-positive and EGFR-negative groups among patients with SC. CONCLUSIONS: In lung cancer cells, the parameters of spectral CT imaging, including NIC and K values, reflect the microvessel density and blood supply. Calcium content is an indicator of the growth status of lung SC.
Authors: Cherry Kim; Wooil Kim; Sung Joon Park; Young Hen Lee; Sung Ho Hwang; Hwan Seok Yong; Yu Whan Oh; Eun Young Kang; Ki Yeol Lee Journal: Korean J Radiol Date: 2020-07 Impact factor: 3.500
Authors: Qing Fu; Shun Li Liu; Da Peng Hao; Ya Bin Hu; Xue Jun Liu; Zaixian Zhang; Wen Hong Wang; Xiao Yan Tang; Chuan Yu Zhang; Shi He Liu Journal: Front Oncol Date: 2021-10-11 Impact factor: 6.244