| Literature DB >> 29751924 |
Cícera Datiane de Morais Oliveira-Tintino1, Saulo Relison Tintino2, Paulo W Limaverde2, Fernando G Figueredo2, Fábia F Campina2, Francisco A B da Cunha2, Roger H S da Costa3, Pedro Silvino Pereira4, Luciene F Lima2, Yedda M L S de Matos2, Henrique Douglas Melo Coutinho5, José P Siqueira-Júnior6, Valdir Q Balbino7, Teresinha Gonçalves da Silva4.
Abstract
This study was carried out to test the essential oil from C. ambrosioides leaves and its main constituent, α-Terpinene, in an antibacterial activity assay. As well, it was evaluated ability reduce resistance to norfloxacin and ethidium bromide was compared the Staphylococcus aureus 1199B whith 1199 wild type strain. The MIC of the C. ambrosioides essential oil and α-Terpinene were determined by microdilution method. The MIC of the essential oil and α-Terpinene presented a value ≥ 1024 μg/mL. However, when associated with antibacterials, the essential oil from C. ambrosioides leaves significantly reduced the MIC of antibiotics and ethidium bromide, characterizing an efflux pump inhibition. The C. ambrosioides essential oil, despite having no direct antibacterial activity against the S. aureus 1199B strain, showed a potentiating action when associated with antibacterial agents, this being attributed to an inhibition of efflux pumps.Entities:
Keywords: Chenopodium ambrosioides L.; Efflux pump inhibitors; Multiresistant bacteria; Staphylococcus aureus
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Year: 2018 PMID： 29751924 DOI： 10.1016/j.foodchem.2018.04.040
Source DB: PubMed Journal: Food Chem ISSN： 0308-8146 Impact factor: 7.514