Jeong Won Lee1, Ho Sung Lee2, Ju Ock Na2, Sang Mi Lee3. 1. Department of Nuclear Medicine, Catholic Kwandong University College of Medicine, International St. Mary's Hospital, Simgok-ro 100 Gil 25, Seo-gu, Incheon 22711, Republic of Korea. 2. Department of Internal Medicine, Soonchunhyang Univeristy Cheonan Hospital, 23-20, Byeongmyeong-dong, Dongnam-gu, Cheonan, Chungcheongnam-do 31151, Republic of Korea. 3. Department of Nuclear Medicine, Soonchunhyang University Cheonan Hospital, 23-20, Byeongmyeong-dong, Dongnam-gu, Cheonan, Chungcheongnam-do 31151, Republic of Korea. Electronic address: c91300@schmc.ac.kr.
Abstract
OBJECTIVE: This study evaluated the relationship between adipose tissue volume and survival in patients with non-small cell lung cancer (NSCLC). METHODS: We retrospectively included 171 NSCLC patients who underwent staging 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) and subsequent curative surgical resection or definite chemoradiotherapy. Maximum standardized uptake value (SUV) of lung cancer normalized by lean body mass (SULmax) and volume and mean SUV of subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) were derived from PET/CT images. The relationships of volume and mean SUV of SAT and VAT with survival were assessed. RESULTS: Of the 171 patients, 79 (46.2%) experienced disease progression and 61 patients (35.7%) died during follow-up. SULmax had significant negative correlation with SAT volume (p = 0.003), but not with VAT volume and mean SUV of SAT and VAT (p > 0.05). On multivariate analysis, advanced TNM stage and high SULmax were significantly related with worse progression-free survival (PFS) and high SAT volume was significantly associated with better PFS (p < 0.05). Patient subgroups of high SULmax (>4.6) and low SAT volume (<75 cm3) had the highest disease progression rate of 61.7%, while other patient subgroups showed rates between 21.1 and 33.3%. SAT volume was significantly related with overall survival on univariate analysis, but failed to show significance on multivariate analysis. Only TNM stage was an independent prognostic factor for overall survival. CONCLUSION: SAT volume had significant favorable effect on PFS in patients with NSCLC.
OBJECTIVE: This study evaluated the relationship between adipose tissue volume and survival in patients with non-small cell lung cancer (NSCLC). METHODS: We retrospectively included 171 NSCLCpatients who underwent staging 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) and subsequent curative surgical resection or definite chemoradiotherapy. Maximum standardized uptake value (SUV) of lung cancer normalized by lean body mass (SULmax) and volume and mean SUV of subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) were derived from PET/CT images. The relationships of volume and mean SUV of SAT and VAT with survival were assessed. RESULTS: Of the 171 patients, 79 (46.2%) experienced disease progression and 61 patients (35.7%) died during follow-up. SULmax had significant negative correlation with SAT volume (p = 0.003), but not with VAT volume and mean SUV of SAT and VAT (p > 0.05). On multivariate analysis, advanced TNM stage and high SULmax were significantly related with worse progression-free survival (PFS) and high SAT volume was significantly associated with better PFS (p < 0.05). Patient subgroups of high SULmax (>4.6) and low SAT volume (<75 cm3) had the highest disease progression rate of 61.7%, while other patient subgroups showed rates between 21.1 and 33.3%. SAT volume was significantly related with overall survival on univariate analysis, but failed to show significance on multivariate analysis. Only TNM stage was an independent prognostic factor for overall survival. CONCLUSION: SAT volume had significant favorable effect on PFS in patients with NSCLC.
Authors: Jeong Won Lee; Sung Yong Kim; Hyun Ju Lee; Sun Wook Han; Jong Eun Lee; Sang Mi Lee Journal: Cancers (Basel) Date: 2019-08-08 Impact factor: 6.639
Authors: Jeong Won Lee; Myoung Won Son; Il Kwon Chung; Young Sin Cho; Moon-Soo Lee; Sang Mi Lee Journal: Gastric Cancer Date: 2019-09-04 Impact factor: 7.370