Literature DB >> 2974881

Suppression of conditioned avoidance by 8-OH-DPAT in the rat.

M L Wadenberg1, S Ahlenius.   

Abstract

Rats were trained to perform an aversely motivated discriminative task in a shuttle-box. The conditioned avoidance response was selectively suppressed by 8-OH-DPAT in a dose-dependent manner (25-100 micrograms.kg-1). There were no statistically significant deficits in discriminative performance. The present results suggest antipsychotic-like properties of 8-OH-DPAT.

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Year:  1988        PMID： 2974881     DOI： 10.1007/bf01244785

Source DB:  PubMed          Journal:  J Neural Transm            Impact factor:   3.575


  3 in total

1.  Effects of low and high doses of L-dopa on the tetrabenazine or alpha-methyltyrosine-induced suppression of behaviour in a successive discrimination task.

Authors:  S Ahlenius
Journal:  Psychopharmacologia       Date:  1974

2.  8-Hydroxy-2-(di-n-propylamino)-tetralin discriminates between subtypes of the 5-HT1 recognition site.

Authors:  D N Middlemiss; J R Fozard
Journal:  Eur J Pharmacol       Date:  1983-05-20       Impact factor: 4.432

3.  (+)-8-OH-DPAT and 5-MeODMT induced analgesia is antagonised by noradrenaline depletion.

Authors:  T Archer; E Arweström; B G Minor; M L Persson; C Post; E Sundström; G Jonsson
Journal:  Physiol Behav       Date:  1987
  3 in total
  5 in total

1.  Antagonism by 8-OH-DPAT, but not ritanserin, of catalepsy induced by SCH 23390 in the rat.

Authors:  M L Wadenberg
Journal:  J Neural Transm Gen Sect       Date:  1992

2.  Antipsychotic-like profile of combined treatment with raclopride and 8-OH-DPAT in the rat: enhancement of antipsychotic-like effects without catalepsy.

Authors:  M L Wadenberg; S Ahlenius
Journal:  J Neural Transm Gen Sect       Date:  1991

3.  Effects of repeated treatment with 5-HT1A agonists on active avoidance responding in the rat.

Authors:  K Ensler; C N Ryan; J L Evenden
Journal:  Psychopharmacology (Berl)       Date:  1993       Impact factor: 4.530

4.  Potency mismatch for behavioral and biochemical effects by dopamine receptor antagonists: implications for the mechanism of action of clozapine.

Authors:  M L Wadenberg; S Ahlenius; T H Svensson
Journal:  Psychopharmacology (Berl)       Date:  1993       Impact factor: 4.530

5.  Effects of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) after repeated administration on a conditioned avoidance response (CAR) in the rat.

Authors:  J L Evenden
Journal:  Psychopharmacology (Berl)       Date:  1992       Impact factor: 4.530
  5 in total

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