Literature DB >> 2974880

Inhibition of p-chlorophenylalanine-induced muricide behavior following TRH microinjection into the limbic structures in the rat.

O Puciłowski1, E Trzaskowska, W Kostowski, E Jankowska, G Kupryszewski.   

Abstract

The effect of central microinjections of thyrotropin releasing hormone (TRH) on muricide behavior was investigated in rats with chronically implanted cannulas into one of the limbic structures: the amygdala, the hippocampus or the nucleus accumbens. The rats were made aggressive by p-chlorophenylalanine administration. Saline injection did not inhibit muricide, whereas TRH (10 micrograms in 0.5 microliter per side) significantly suppressed mouse-killing reaction upon injection into each of three regions. It is suggested that the observed antiaggressive effect of TRH may involve stimulation of the central noradrenergic and/or serotonergic transmission.

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Year:  1988        PMID： 2974880     DOI： 10.1007/bf01244783

Source DB:  PubMed          Journal:  J Neural Transm            Impact factor:   3.575


  17 in total

Review 1.  Central catecholamine neuron systems: anatomy and physiology of the norepinephrine and epinephrine systems.

Authors:  R Y Moore; F E Bloom
Journal:  Annu Rev Neurosci       Date:  1979       Impact factor: 12.449

Review 2.  Aggressive behaviour and the central serotonergic systems.

Authors:  O Pucilowski; W Kostowski
Journal:  Behav Brain Res       Date:  1983-07       Impact factor: 3.332

3.  Chlordiazepoxide antagonizes locus coeruleus-mediated suppression of muricidal aggression.

Authors:  W Kostowski; L Valzelli; W Kozak
Journal:  Eur J Pharmacol       Date:  1983-07-22       Impact factor: 4.432

4.  Thyrotropin releasing hormone and its analogues I. New syntheses and biological properties of TRH (Pro-NH-NH2)3-TRH and (2-Picolyl)-TRH.

Authors:  J Bobrowska; P Leroux; E Maliński; J Przybylski; J Szafranek; M C Tonon; H Vaudry; G Kupryszewski
Journal:  Mater Med Pol       Date:  1980 Jan-Jun

5.  Enhancement of cerebral noradrenaline turnover by thyrotropin-releasing hormone.

Authors:  H H Keller; G Bartholini; A Pletscher
Journal:  Nature       Date:  1974-04-05       Impact factor: 49.962

6.  Norepinephrine metabolism in the rat brain following acute and chronic administration of thyrotropin releasing hormone.

Authors:  T G Reigle; J Avni; P A Platz; J J Schildkraut; N P Plotnikoff
Journal:  Psychopharmacologia       Date:  1974-06-18

7.  Various types of thyrotropin-releasing hormone receptors in discrete brain regions and the pituitary of the rat.

Authors:  K Funatsu; S Teshima; K Inanaga
Journal:  J Neurochem       Date:  1985-08       Impact factor: 5.372

8.  The effects of 5,7-dihydroxytryptamine and p-chlorophenylalanine on thyrotrophin-releasing hormone in regions of the brain and spinal cord of the rat.

Authors:  C Lighton; C A Marsden; G W Bennett
Journal:  Neuropharmacology       Date:  1984-01       Impact factor: 5.250

9.  Inhibition of affective aggression and dominance in rats after thyrotropin-releasing hormone (TRH) microinjection into the nucleus accumbens.

Authors:  O Puciłowski; E Trzaskowska; W Kostowski; W Wośko
Journal:  Peptides       Date:  1988 May-Jun       Impact factor: 3.750

10.  Anxiolytic activity on locus coeruleus-mediated suppression of muricidal aggression.

Authors:  W Kozak; L Valzelli; S Garattini
Journal:  Eur J Pharmacol       Date:  1984-10-15       Impact factor: 4.432
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