| Literature DB >> 29748278 |
Simon J O'Hanlon1,2, Adrien Rieux3, Rhys A Farrer4, Gonçalo M Rosa2,5,6, Bruce Waldman7, Arnaud Bataille7,8, Tiffany A Kosch7,9, Kris A Murray4, Balázs Brankovics10,11, Matteo Fumagalli12,13, Michael D Martin14,15, Nathan Wales15, Mario Alvarado-Rybak16, Kieran A Bates4,2, Lee Berger9, Susanne Böll17, Lola Brookes2, Frances Clare4,2, Elodie A Courtois18, Andrew A Cunningham2, Thomas M Doherty-Bone19, Pria Ghosh4,20, David J Gower21, William E Hintz22, Jacob Höglund23, Thomas S Jenkinson24, Chun-Fu Lin25, Anssi Laurila23, Adeline Loyau26,27, An Martel28, Sara Meurling23, Claude Miaud29, Pete Minting30, Frank Pasmans28, Dirk S Schmeller26,27, Benedikt R Schmidt31, Jennifer M G Shelton4, Lee F Skerratt9, Freya Smith2,32, Claudio Soto-Azat16, Matteo Spagnoletti13, Giulia Tessa33, Luís Felipe Toledo34, Andrés Valenzuela-Sánchez16,35, Ruhan Verster20, Judit Vörös36, Rebecca J Webb9, Claudia Wierzbicki4, Emma Wombwell2, Kelly R Zamudio37, David M Aanensen4,38, Timothy Y James24, M Thomas P Gilbert14,15, Ché Weldon20, Jaime Bosch39, François Balloux13, Trenton W J Garner2,20,33, Matthew C Fisher1.
Abstract
Globalized infectious diseases are causing species declines worldwide, but their source often remains elusive. We used whole-genome sequencing to solve the spatiotemporal origins of the most devastating panzootic to date, caused by the fungus Batrachochytrium dendrobatidis, a proximate driver of global amphibian declines. We traced the source of B. dendrobatidis to the Korean peninsula, where one lineage, BdASIA-1, exhibits the genetic hallmarks of an ancestral population that seeded the panzootic. We date the emergence of this pathogen to the early 20th century, coinciding with the global expansion of commercial trade in amphibians, and we show that intercontinental transmission is ongoing. Our findings point to East Asia as a geographic hotspot for B. dendrobatidis biodiversity and the original source of these lineages that now parasitize amphibians worldwide.Entities:
Mesh：
Year: 2018 PMID： 29748278 PMCID： PMC6311102 DOI： 10.1126/science.aar1965
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728