Literature DB >> 29747982

Asthma Over the Age of 65: All's Well That Ends Well.

Alan P Baptist1, Paula J Busse2.   

Abstract

Asthma in older adults (often classified as those 65 years or older) is relatively common, underdiagnosed, and suboptimally treated. It is an important health problem, as the population of the United States continues to age. Unfortunately, asthma morbidity and mortality rates are highest in this age group. Alterations in the innate and adaptive immune responses occur with aging, and contribute to pathophysiologic differences and subsequent treatment challenges. The symptoms of asthma may differ from those in younger populations, and often include fatigue. There are unique factors that can complicate asthma management among older adults, including comorbidities, menopause, caregiver roles, and depression. Pharmacologic therapies are often not as effective as in younger populations, and may have greater side effects. Spirometry, peak flow measurements, and asthma education are typically underused, and may contribute to delays in diagnosis as well as worse outcomes. There are specific strategies that health care providers can take to improve the care of older adults with asthma.
Copyright © 2018 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Asthma; Asthma COPD overlap syndrome; Depression; Education; Elderly; Immunosenescence; Menopause; Older adults; Spirometry

Mesh:

Substances:

Year:  2018        PMID: 29747982      PMCID: PMC5951417          DOI: 10.1016/j.jaip.2018.02.007

Source DB:  PubMed          Journal:  J Allergy Clin Immunol Pract


  154 in total

1.  Underuse of inhaled steroid therapy in elderly patients with asthma.

Authors:  D D Sin; J V Tu
Journal:  Chest       Date:  2001-03       Impact factor: 9.410

2.  Asthma Morbidity, Comorbidities, and Modifiable Factors Among Older Adults.

Authors:  Joy Hsu; Jessica Chen; Maria C Mirabelli
Journal:  J Allergy Clin Immunol Pract       Date:  2017-07-26

3.  Menopause as a predictor of new-onset asthma: A longitudinal Northern European population study.

Authors:  Kai Triebner; Ane Johannessen; Luca Puggini; Bryndís Benediktsdóttir; Randi J Bertelsen; Ersilia Bifulco; Shyamali C Dharmage; Julia Dratva; Karl A Franklin; Thórarinn Gíslason; Mathias Holm; Deborah Jarvis; Bénédicte Leynaert; Eva Lindberg; Andrei Malinovschi; Ferenc Macsali; Dan Norbäck; Ernst R Omenaas; Francisco J Rodríguez; Eirunn Saure; Vivi Schlünssen; Torben Sigsgaard; Trude D Skorge; Gunilla Wieslander; Elisabeth Zemp; Cecilie Svanes; Steinar Hustad; Francisco Gómez Real
Journal:  J Allergy Clin Immunol       Date:  2015-10-02       Impact factor: 10.793

4.  Age-related increases in PGD(2) expression impair respiratory DC migration, resulting in diminished T cell responses upon respiratory virus infection in mice.

Authors:  Jincun Zhao; Jingxian Zhao; Kevin Legge; Stanley Perlman
Journal:  J Clin Invest       Date:  2011-11-21       Impact factor: 14.808

5.  Montelukast as an add-on therapy to inhaled corticosteroids in the treatment of severe asthma in elderly patients.

Authors:  Andrzej Bozek; Barbara Warkocka-Szoltysek; Agata Filipowska-Gronska; Jerzy Jarzab
Journal:  J Asthma       Date:  2012-05-03       Impact factor: 2.515

6.  Phenotype of normal spirometry in an aging population.

Authors:  Carlos A Vaz Fragoso; Gail McAvay; Peter H Van Ness; Richard Casaburi; Robert L Jensen; Neil MacIntyre; Thomas M Gill; H Klar Yaggi; John Concato
Journal:  Am J Respir Crit Care Med       Date:  2015-10-01       Impact factor: 21.405

7.  Efficacy of injection immunotherapy with ragweed and birch pollen in elderly patients.

Authors:  Riccardo Asero
Journal:  Int Arch Allergy Immunol       Date:  2004-11-24       Impact factor: 2.749

8.  Bupropion in the treatment of outpatients with asthma and major depressive disorder.

Authors:  E Sherwood Brown; Lana A Vornik; David A Khan; A John Rush
Journal:  Int J Psychiatry Med       Date:  2007       Impact factor: 1.210

Review 9.  Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases.

Authors:  Claudio Franceschi; Judith Campisi
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2014-06       Impact factor: 6.053

10.  Descriptions of barriers to self-care by persons with comorbid chronic diseases.

Authors:  Elizabeth A Bayliss; John F Steiner; Douglas H Fernald; Lori A Crane; Deborah S Main
Journal:  Ann Fam Med       Date:  2003 May-Jun       Impact factor: 5.166

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  6 in total

1.  Characterisation of the Australian Adult Population Living with Asthma: Severe - Exacerbation Frequency, Long-Term OCS Use and Adverse Effects.

Authors:  Kerry L Hancock; Sinthia Bosnic-Anticevich; John D Blakey; Mark Hew; Li Ping Chung; Biljana Cvetkovski; Scott Claxton; Peter Del Fante; Eve Denton; Joe Doan; Kanchanamala Ranasinghe; Lucy Morgan; Anita Sharma; Peter K Smith; Deb Stewart; Philip J Thompson; Russell Wiseman; John W Upham; Kwok Y Yan; Victoria Carter; Kiranjeet Dhillon; Florian Heraud; Thao Le; Rebecca Vella; David Price
Journal:  Pragmat Obs Res       Date:  2022-07-05

2.  Asthma: Overdiagnosed, Underdiagnosed, and Ineffectively Treated.

Authors:  Ann Chen Wu; Paul A Greenberger
Journal:  J Allergy Clin Immunol Pract       Date:  2018 May - Jun

3.  Short palate, lung, and nasal epithelial clone 1 (SPLUNC1) level determines steroid-resistant airway inflammation in aging.

Authors:  Anil Kumar Jaiswal; Jyoti Yadav; Sangeet Makhija; Maninder Sandey; Amol Suryawanshi; Amit Kumar Mitra; Amarjit Mishra
Journal:  Am J Physiol Lung Cell Mol Physiol       Date:  2021-12-01       Impact factor: 5.464

4.  Vitamin D status and asthma, lung function, and hospitalization among British adults.

Authors:  Yiqun Zhu; Danrong Jing; Huaying Liang; Dianwu Li; Qinyu Chang; Minxue Shen; Pinhua Pan; Hong Liu; Yan Zhang
Journal:  Front Nutr       Date:  2022-08-10

Review 5.  Sex, Cells, and Asthma.

Authors:  Sergio E Chiarella; Juan Carlos Cardet; Y S Prakash
Journal:  Mayo Clin Proc       Date:  2021-07       Impact factor: 11.104

Review 6.  Mitochondrial Dysfunction in Chronic Respiratory Diseases: Implications for the Pathogenesis and Potential Therapeutics.

Authors:  Wen-Cheng Zhou; Jiao Qu; Sheng-Yang Xie; Yang Sun; Hong-Wei Yao
Journal:  Oxid Med Cell Longev       Date:  2021-07-27       Impact factor: 6.543

  6 in total

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