John F McNamara1, Elda Righi2, Hugh Wright3, Gunter F Hartel4, Patrick N A Harris3, David L Paterson3. 1. Centre for Clinical Research, Royal Brisbane and Women's Hospital, University of Queensland, Building 71/918, Brisbane QLD 4029, Australia; The Prince Charles Hospital, Chermside, Brisbane, Australia. Electronic address: mcnamarajfg@gmail.com. 2. Centre for Clinical Research, Royal Brisbane and Women's Hospital, University of Queensland, Building 71/918, Brisbane QLD 4029, Australia; Infectious Diseases Division, Santa Maria della Misericordia University Hospital, Udine, Italy. 3. Centre for Clinical Research, Royal Brisbane and Women's Hospital, University of Queensland, Building 71/918, Brisbane QLD 4029, Australia. 4. Statistics Group, Berghofer Centre, Queensland Institute of Medical Research, Brisbane, Australia.
Abstract
OBJECTIVES: Bloodstream infection results in significant short-term morbidity and mortality. No literature review has studied the long-term outcome following a bloodstream infection. This PROSPERO registered systematic review evaluated studies, which measured the association of a bloodstream infection with long-term morbidity and mortality. METHODS: Databases were systematically searched for studies of adult patients reporting morbidity and/or mortality one year or more following a bloodstream infection in comparison to a matched cohort without a bloodstream infection. RESULTS: Ten observational studies were included in the final analysis. Five studies assessed only mortality, two assessed morbidity and mortality and three studies assessed morbidity only. The one year mortality ranged from between 8 and 48% for patients with bloodstream infection. The pooled risk ratio of death at one year was significantly higher for patients with bloodstream infection when compared to the matched cohort (RR 4.04 [95% CI 1.84-8.87]). CONCLUSIONS: Bloodstream infection was associated with poor long-term outcome measured at one year when compared to matched controls. More evidence is needed to determine if this association is causative.
OBJECTIVES: Bloodstream infection results in significant short-term morbidity and mortality. No literature review has studied the long-term outcome following a bloodstream infection. This PROSPERO registered systematic review evaluated studies, which measured the association of a bloodstream infection with long-term morbidity and mortality. METHODS: Databases were systematically searched for studies of adult patients reporting morbidity and/or mortality one year or more following a bloodstream infection in comparison to a matched cohort without a bloodstream infection. RESULTS: Ten observational studies were included in the final analysis. Five studies assessed only mortality, two assessed morbidity and mortality and three studies assessed morbidity only. The one year mortality ranged from between 8 and 48% for patients with bloodstream infection. The pooled risk ratio of death at one year was significantly higher for patients with bloodstream infection when compared to the matched cohort (RR 4.04 [95% CI 1.84-8.87]). CONCLUSIONS: Bloodstream infection was associated with poor long-term outcome measured at one year when compared to matched controls. More evidence is needed to determine if this association is causative.
Authors: Heather A King; Sarah B Doernberg; Julie Miller; Kiran Grover; Megan Oakes; Felicia Ruffin; Sarah Gonzales; Abigail Rader; Michael J Neuss; Hayden B Bosworth; Zoë Sund; Caitlin Drennan; Jonathan M Hill-Rorie; Pratik Shah; Laura Winn; Vance G Fowler; Thomas L Holland Journal: Clin Infect Dis Date: 2021-07-15 Impact factor: 9.079
Authors: Daniel J Diekema; Po-Ren Hsueh; Rodrigo E Mendes; Michael A Pfaller; Kenneth V Rolston; Helio S Sader; Ronald N Jones Journal: Antimicrob Agents Chemother Date: 2019-06-24 Impact factor: 5.191