Literature DB >> 29745410

hIAPP forms toxic oligomers in plasma.

Diana C Rodriguez Camargo1, Divita Garg, Katalin Buday, Andras Franko, Andres Rodriguez Camargo, Fabian Schmidt, Sarah J Cox, Saba Suladze, Martin Haslbeck, Yonatan G Mideksa, Gerd Gemmecker, Michaela Aichler, Gabriele Mettenleiter, Michael Schulz, Axel Karl Walch, Martin Hrabě de Angelis, Matthias J Feige, Cesar A Sierra, Marcus Conrad, Konstantinos Tripsianes, Ayyalusamy Ramamoorthy, Bernd Reif.   

Abstract

In diabetes, hyperamylinemia contributes to cardiac dysfunction. The interplay between hIAPP, blood glucose and other plasma components is, however, not understood. We show that glucose and LDL interact with hIAPP, resulting in β-sheet rich oligomers with increased β-cell toxicity and hemolytic activity, providing mechanistic insights for a direct link between diabetes and cardiovascular diseases.

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Year:  2018        PMID： 29745410      PMCID： PMC5970100          DOI： 10.1039/c8cc03097a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  38 in total

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3.  Islet amyloid formation associated with hyperglycemia in transgenic mice with pancreatic beta cell expression of human islet amyloid polypeptide.

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Journal:  Proc Natl Acad Sci U S A       Date:  1996-04-16       Impact factor: 11.205

4.  Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients.

Authors:  G J Cooper; A C Willis; A Clark; R C Turner; R B Sim; K B Reid
Journal:  Proc Natl Acad Sci U S A       Date:  1987-12       Impact factor: 11.205

5.  Effects of meal ingestion on plasma amylin concentration in NIDDM and nondiabetic humans.

Authors:  P C Butler; J Chou; W B Carter; Y N Wang; B H Bu; D Chang; J K Chang; R A Rizza
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6.  Aberrant processing of human proislet amyloid polypeptide results in increased amyloid formation.

Authors:  Johan F Paulsson; Gunilla T Westermark
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Review 8.  Diabetic cardiomyopathy revisited.

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4.  Nanoscale Surface Topography Modulates hIAPP Aggregation Pathways at Solid-Liquid Interfaces.

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  4 in total

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