Chaitrali Gijare1, Ashwini Deshpande1.
Abstract
BACKGROUND: Nowadays, Oral Film Technology (OFT) has gained much attention among all the oral drug delivery systems. Fast dissolving film, fast disintegrating film, and orodispersible film are some synonymous words for this dosage form. Without a need of liquid for administration, this dosage form dissolves in the mouth. Typically, fast dissolving film dissolves from 1 to 30 seconds.
OBJECTIVE: At the root of its originality, many researchers patented their work on the aspect of orodispersible films using different drugs, polymers, excipients and employing various methods of preparation. The review focuses on details related to orodispersible films and their patents from 1979-2017, collected from various sources like USPTO, Google patent, Espacenet, Intellectual Property India.
RESULTS: For the ease of discussion, collected patents are segregated on the basis of drugs, polymers, and method of preparation. It was found that many researchers are shifting towards fast dissolving films for better patient compliance, extended efficacy, high bioavailability, fast dissolution, and disintegration. With the help of polymers blend suitable for the drug release and improved method of preparation various parameters like tensile strength, thickness, and pH etc. can be controlled.
CONCLUSION: It was observed that judicial selection of polymers and polymers blends and methods of preparation are key parameters in the formulation of orodispersible film. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.
BACKGROUND: Nowadays, Oral Film Technology (OFT) has gained much attention among all the oral drug delivery systems. Fast dissolving film, fast disintegrating film, and orodispersible film are some synonymous words for this dosage form. Without a need of liquid for administration, this dosage form dissolves in the mouth. Typically, fast dissolving film dissolves from 1 to 30 seconds.
OBJECTIVE: At the root of its originality, many researchers patented their work on the aspect of orodispersible films using different drugs, polymers, excipients and employing various methods of preparation. The review focuses on details related to orodispersible films and their patents from 1979-2017, collected from various sources like USPTO, Google patent, Espacenet, Intellectual Property India.
RESULTS: For the ease of discussion, collected patents are segregated on the basis of drugs, polymers, and method of preparation. It was found that many researchers are shifting towards fast dissolving films for better patient compliance, extended efficacy, high bioavailability, fast dissolution, and disintegration. With the help of polymers blend suitable for the drug release and improved method of preparation various parameters like tensile strength, thickness, and pH etc. can be controlled.
CONCLUSION: It was observed that judicial selection of polymers and polymers blends and methods of preparation are key parameters in the formulation of orodispersible film. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.
Entities:
Keywords:
Orodispersible films; efficacy; gelatin capsules; patents; patient compliance; polymers.
Mesh：
Substances：
Year: 2018
PMID： 29745346 DOI： 10.2174/1872211312666180509100216
Source DB: PubMed Journal: Recent Pat Drug Deliv Formul ISSN： 1872-2113