Literature DB >> 2974471

T cell subsets and disease progression after total lymphoid irradiation in chronic progressive multiple sclerosis.

R Troiano1, C Devereux, J Oleske, T Denny, M Hafstein, G Zito, C Rohowski-Kochan, P C Dowling, S D Cook.   

Abstract

T lymphocyte subset percentages were determined in 16 total lymphoid irradiation (TLI) treated and 18 sham treated control patients with chronic progressive multiple sclerosis. During the first year after treatment, the ratio of T helper/inducer to T suppressor/cytotoxic cells (Th/Ts ratio) was significantly higher in sham treated multiple sclerosis patients who worsened clinically compared with TLI treated and sham treated multiple sclerosis patients who remained clinically stable. TLI caused a fall in the percentage of T helper cells in treated patients, while the percentage of T suppressor cells remained stable during the first year after treatment. In contrast, the percentage of T suppressor cells fell in sham treated multiple sclerosis patients who worsened clinically.

Entities:  

Mesh：

Year:  1988        PMID： 2974471      PMCID： PMC1033204          DOI： 10.1136/jnnp.51.7.980

Source DB:  PubMed          Journal:  J Neurol Neurosurg Psychiatry        ISSN： 0022-3050            Impact factor:   10.154


  13 in total

1.  Lymphoid irradiation in intractable rheumatoid arthritis. A double-blind, randomized study comparing 750-rad treatment with 2,000-rad treatment.

Authors:  J G Hanly; J Hassan; M Moriarty; C Barry; J Molony; E Casey; A Whelan; C Feighery; B Bresnihan
Journal:  Arthritis Rheum       Date:  1986-01

2.  Treatment of intractable lupus nephritis with total lymphoid irradiation.

Authors:  S Strober; E Field; R T Hoppe; B L Kotzin; O Shemesh; E Engleman; J C Ross; B D Myers
Journal:  Ann Intern Med       Date:  1985-04       Impact factor: 25.391

3.  Suppressor T-lymphocytes in multiple sclerosis: analysis of patients with acute relapsing and chronic progressive disease.

Authors:  D W Paty; L Kastrukoff; N Morgan; L Hiob
Journal:  Ann Neurol       Date:  1983-10       Impact factor: 10.422

4.  Total lymphoid irradiation therapy in refractory rheumatoid arthritis. Fifteen- to forty-month followup.

Authors:  E Brahn; S M Helfgott; J A Belli; R J Anderson; E L Reinherz; S F Schlossman; K F Austen; D E Trentham
Journal:  Arthritis Rheum       Date:  1984-05

5.  Loss of suppressor T cells in active multiple sclerosis. Analysis with monoclonal antibodies.

Authors:  E L Reinherz; H L Weiner; S L Hauser; J A Cohen; J A Distaso; S F Schlossman
Journal:  N Engl J Med       Date:  1980-07-17       Impact factor: 91.245

6.  Selective loss of a subset of T helper cells in active multiple sclerosis.

Authors:  L M Rose; A H Ginsberg; T L Rothstein; J A Ledbetter; E A Clark
Journal:  Proc Natl Acad Sci U S A       Date:  1985-11       Impact factor: 11.205

7.  Deficit of suppressor T cells in active multiple sclerosis.

Authors:  M A Bach; F Phan-Dinh-Tuy; E Tournier; L Chatenoud; J F Bach; C Martin; J D Degos
Journal:  Lancet       Date:  1980-12-06       Impact factor: 79.321

8.  Effect of total lymphoid irradiation in chronic progressive multiple sclerosis.

Authors:  S D Cook; C Devereux; R Troiano; M P Hafstein; G Zito; E Hernandez; M Lavenhar; R Vidaver; P C Dowling
Journal:  Lancet       Date:  1986-06-21       Impact factor: 79.321

9.  Peripheral blood T lymphocyte changes in multiple sclerosis: a marker of disease progression rather than of relapse?

Authors:  A J Thompson; J Brazil; C A Whelan; E A Martin; M Hutchinson; C Feighery
Journal:  J Neurol Neurosurg Psychiatry       Date:  1986-08       Impact factor: 10.154

10.  Long-term followup of rheumatoid arthritis patients treated with total lymphoid irradiation.

Authors:  A Tanay; E H Field; R T Hoppe; S Strober
Journal:  Arthritis Rheum       Date:  1987-01
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