Mehran Rahimlou1,2, Nava Morshedzadeh3, Soheila Karimi4, Sima Jafarirad5. 1. Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. 2. Department of Nutrition, School of Para-medicine, Ahvaz Jundishapur University of Medical Sciences, Golestan, Farvardin Blvd., Esfand St., P.O.Box: 19395-3512, 61357-15794, Ahvaz, Iran. 3. Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 4. Nutrition and Endocrine Research Center, Research Institute for Endocrine Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 5. Department of Nutrition, School of Para-medicine, Ahvaz Jundishapur University of Medical Sciences, Golestan, Farvardin Blvd., Esfand St., P.O.Box: 19395-3512, 61357-15794, Ahvaz, Iran. sjafarirad@gmail.com.
Abstract
BACKGROUND: A combination of genetic and environmental factors is involved in depression etiology. During the last years, the prevalence of depression has increased in both developed and developing countries. Several studies indicated an association between dietary glycemic index (GI) and glycemic load (GL) with risk of depression. This systematic review was undertaken to summarize the effect of these diet indicators in depression pathogenesis. METHODS: A comprehensive search strategy was performed in the Pubmed, Embase, Cochrane Library and Scopus databases from 1966 to March 2017. Finally, six studies (three prospective cohort studies and three cross-sectional) were ultimately selected for inclusion in the systematic review. RESULTS: 75298 adults and elderly entered the reviewed studies. All of the included studies had high methodological quality. The present study indicated that the intake of foods with higher GI is associated with disease risk. However, the relationship was found to be inverse for GL, though the association was rather weak. CONCLUSIONS: Overall, the findings indicated that a diet with lower dietary glycemic index may be effective to reduce the risk or risk of depression.
BACKGROUND: A combination of genetic and environmental factors is involved in depression etiology. During the last years, the prevalence of depression has increased in both developed and developing countries. Several studies indicated an association between dietary glycemic index (GI) and glycemic load (GL) with risk of depression. This systematic review was undertaken to summarize the effect of these diet indicators in depression pathogenesis. METHODS: A comprehensive search strategy was performed in the Pubmed, Embase, Cochrane Library and Scopus databases from 1966 to March 2017. Finally, six studies (three prospective cohort studies and three cross-sectional) were ultimately selected for inclusion in the systematic review. RESULTS: 75298 adults and elderly entered the reviewed studies. All of the included studies had high methodological quality. The present study indicated that the intake of foods with higher GI is associated with disease risk. However, the relationship was found to be inverse for GL, though the association was rather weak. CONCLUSIONS: Overall, the findings indicated that a diet with lower dietary glycemic index may be effective to reduce the risk or risk of depression.
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