Literature DB >> 2974423

Autoreactive T cells in mercury-induced autoimmunity. Demonstration by limiting dilution analysis.

J Rossert1, L Pelletier, R Pasquier, P Druet.   

Abstract

Mercuric chloride is responsible in Brown-Norway rats for an autoimmune disease that is autoregulated. Previous studies have shown that this agent induces T cell-dependent polyclonal B cell activation in these rats. Evidence has also been obtained for the existence of autoreactive T cells which play a role in the evolution of this process. In the present study, limiting dilution analysis was used to demonstrate that (a) frequent autoreactive T helper cells which proliferate in the presence of T cells from HgCl2-injected rats are present from day 4; (b) frequent auto-anti-Ia T helper cells which recognize normal B cells as well as B cells from HgCl2-injected rats appear from day 6; and (c) less frequent T suppressor cells which could play a role in autoregulation emerge from day 14.

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Year:  1988        PMID： 2974423     DOI： 10.1002/eji.1830181116

Source DB:  PubMed          Journal:  Eur J Immunol        ISSN： 0014-2980            Impact factor:   5.532


  10 in total

1.  Mercury-induced autoreactive anti-class II T cell line protects from experimental autoimmune encephalomyelitis by the bias of CD8+ antiergotypic cells in Lewis rats.

Authors:  M Castedo; L Pelletier; J Rossert; R Pasquier; H Villarroya; P Druet
Journal:  J Exp Med       Date:  1993-04-01       Impact factor: 14.307

2.  Graft-versus-host reactions in the rat mimic toxin-induced autoimmunity.

Authors:  H Tournade; L Pelletier; R Pasquier; M C Vial; C Mandet; P Druet
Journal:  Clin Exp Immunol       Date:  1990-08       Impact factor: 4.330

3.  Resistance to re-challenge in the Brown Norway rat model of vasculitis is not always complete and may reveal separate effector and regulatory populations.

Authors:  C S Vinen; D R Turner; D B G Oliveira
Journal:  Immunology       Date:  2004-10       Impact factor: 7.397

Review 4.  The inflammatory function of renal glomerular mesangial cells and their interaction with the cellular immune system.

Authors:  H H Radeke; K Resch
Journal:  Clin Investig       Date:  1992-09

5.  Allogeneic hematolymphoid microchimerism and prevention of autoimmune disease in the rat. A relationship between allo- and autoimmunity.

Authors:  C P Delaney; N Murase; M Chen-Woan; J J Fung; T E Starzl; A J Demetris
Journal:  J Clin Invest       Date:  1996-01-01       Impact factor: 14.808

6.  The Th2-response in mercuric chloride-induced autoimmunity requires continuing costimulation via CD28.

Authors:  I A M Macphee; D R Turner; H Yagita; D B G Oliveira
Journal:  Clin Exp Immunol       Date:  2002-09       Impact factor: 4.330

7.  Transforming growth factor beta (TGF-beta)-dependent inhibition of T helper cell 2 (Th2)-induced autoimmunity by self-major histocompatibility complex (MHC) class II-specific, regulatory CD4(+) T cell lines.

Authors:  F Bridoux; A Badou; A Saoudi; I Bernard; E Druet; R Pasquier; P Druet; L Pelletier
Journal:  J Exp Med       Date:  1997-05-19       Impact factor: 14.307

8.  Therapeutic effect of all-trans-retinoic acid (at-RA) on an autoimmune nephritis experimental model: role of the VLA-4 integrin.

Authors:  María M Escribese; Elisa Conde; Ana Martín; David Sáenz-Morales; David Sancho; Guillermo Pérez de Lema; Javier Lucio-Cazaña; Francisco Sánchez-Madrid; María L García-Bermejo; Francisco M Mampaso
Journal:  BMC Nephrol       Date:  2007-01-24       Impact factor: 2.388

9.  Regulatory role of OX22high T cells in mercury-induced autoimmunity in the brown Norway rat.

Authors:  P W Mathieson; S Thiru; D B Oliveira
Journal:  J Exp Med       Date:  1993-05-01       Impact factor: 14.307

Review 10.  Immunotoxicity of heavy metals in relation to Great Lakes.

Authors:  J Bernier; P Brousseau; K Krzystyniak; H Tryphonas; M Fournier
Journal:  Environ Health Perspect       Date:  1995-12       Impact factor: 9.031
  10 in total

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