Kellie Ryan1, Sudeep Karve1, Pascale Peeters2, Elisa Baelen3, Danielle Potter4, Sonia Rojas-Farreras5, Esther Pascual6, Jesús Rodríguez-Baño7. 1. AstraZeneca, Health Economics and Outcomes Research, Gaithersburg, MD, USA. 2. IQVIA, Real-World Insights, Saint-Ouen, France. 3. IQVIA, Real-World Insights, St Prex, Switzerland. 4. AstraZeneca, Medical Evidence and Observational Research Center, Gaithersburg, MD, USA. 5. IQVIA, Real-World Insights, Barcelona, Spain. 6. AstraZeneca, Medical Evidence and Observational Research Center, Cambridge, United Kingdom. 7. Unidad Clínica de Enfermedades Infecciosas y Microbiología, Servicio de Enfermedades Infecciosas, Hospital Universitario Virgen Macarena - IBiS, Avda Dr Fedriani 3, 41009 Seville, Spain; Departamento de Medicina, Universidad de Sevilla, Seville, Spain. Electronic address: jesus.rodriguez.bano.sspa@juntadeandalucia.es.
Abstract
OBJECTIVES: To assess real-world treatment patterns and clinical outcomes associated with initial antibiotic therapy (IAT, antibiotics received ≤ 48 h post-initiation of antibiotic therapy), including level of IAT failure, and potential risk factors for IAT failure in healthcare-associated infections. METHODS: Data were obtained from medical records of adult patients hospitalized with healthcare-associated pneumonia (HCAP) and nosocomial pneumonia (NP), including ventilator-associated pneumonia, from 1 July 2013 to 30 June 2014 in Brazil, France, Italy, Russia and Spain during the retrospective, observational study, RECOMMEND (NCT02364284; D4280R00005). Potential risk factors for IAT failure were explored using logistic regression analyses. RESULTS: Mean (standard deviation) age and Deyo-Charlson Comorbidity Score were 66.0 (16.2) years and 2.4 (2.4), respectively (N = 451). Most patients (62.5%) received monotherapy. Mean (standard deviation) duration of IAT was 8.8 (7.2) days. Multidrug-resistant (MDR) pathogens were identified in 52.4% of patients with ≥ 1 pathogen isolated (154/294). IAT failure was recorded in 72.5% of patients and was significantly associated with isolation of a MDR pathogen and country using multivariate analyses. CONCLUSIONS: Real-world data demonstrate the burden of HCAP/NP, with high rates of IAT failure. The association of IAT failure with MDR pathogens highlights the urgent need to understand and account for local prevalence of MDR pathogens when selecting IAT for the management of HCAP/NP.
OBJECTIVES: To assess real-world treatment patterns and clinical outcomes associated with initial antibiotic therapy (IAT, antibiotics received ≤ 48 h post-initiation of antibiotic therapy), including level of IAT failure, and potential risk factors for IAT failure in healthcare-associated infections. METHODS: Data were obtained from medical records of adult patients hospitalized with healthcare-associated pneumonia (HCAP) and nosocomial pneumonia (NP), including ventilator-associated pneumonia, from 1 July 2013 to 30 June 2014 in Brazil, France, Italy, Russia and Spain during the retrospective, observational study, RECOMMEND (NCT02364284; D4280R00005). Potential risk factors for IAT failure were explored using logistic regression analyses. RESULTS: Mean (standard deviation) age and Deyo-Charlson Comorbidity Score were 66.0 (16.2) years and 2.4 (2.4), respectively (N = 451). Most patients (62.5%) received monotherapy. Mean (standard deviation) duration of IAT was 8.8 (7.2) days. Multidrug-resistant (MDR) pathogens were identified in 52.4% of patients with ≥ 1 pathogen isolated (154/294). IAT failure was recorded in 72.5% of patients and was significantly associated with isolation of a MDR pathogen and country using multivariate analyses. CONCLUSIONS: Real-world data demonstrate the burden of HCAP/NP, with high rates of IAT failure. The association of IAT failure with MDR pathogens highlights the urgent need to understand and account for local prevalence of MDR pathogens when selecting IAT for the management of HCAP/NP.
Authors: Wenwen Huo; Lindsay M Busch; Juan Hernandez-Bird; Efrat Hamami; Christopher W Marshall; Edward Geisinger; Vaughn S Cooper; Tim van Opijnen; Jason W Rosch; Ralph R Isberg Journal: Nat Microbiol Date: 2022-05-26 Impact factor: 30.964
Authors: Matteo Bassetti; Souha S Kanj; Pattarachai Kiratisin; Camilla Rodrigues; David Van Duin; María Virginia Villegas; Yunsong Yu Journal: JAC Antimicrob Resist Date: 2022-09-13