| Literature DB >> 29741883 |
Peng-Xiang Shen1, Liang Hu1, Qian Shao1, Kai Hong1, Jin-Quan Yu1.
Abstract
A monoprotected aminoethyl amine chiral ligand based on an ethylenediamine backbone was developed to achieve Pd-catalyzed enantioselective C(sp3)-H arylation of cyclopropanecarboxylic and 2-aminoisobutyric acids without using exogenous directing groups. This new chiral catalyst affords new disconnection for preparing diverse chiral carboxylic acids from simple starting materials that are complementary to the various ring forming approaches.Entities:
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Year: 2018 PMID： 29741883 PMCID： PMC6038808 DOI： 10.1021/jacs.8b03509
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419