Dan Tan1,2,3,4, Feng-Mei Pang1,2,3,4, Dan Li1,2,3,4, Longbo Zhang5, Jun Wu5, Zhao-Qian Liu1,2,3,4, Xi Li1,2,3,4, Han Yan6,7. 1. Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, PR China. 2. Institute of Clinical Pharmacology, Central South University, Changsha, Hunan, PR China. 3. Hunan Key Laboratory of Pharmacogenetics, Changsha, Hunan, 410078, PR China. 4. National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, 410011, PR China. 5. Department of Neurosurgery, Xiangya Hospital, Center South University, Changsha, Hunan, 410008, PR China. 6. Institute of Clinical Pharmacy, Central South University, Changsha, Hunan, 410011, PR China. 7. Department of Pharmacy, The Second Xiangya Hospital, Central South University Changsha, Hunan, 410011, PR China.
Abstract
AIM: To confirm whether the expression level of Fn14 could affect progression or prognosis of glioma patients. METHODS: Glioma cohorts in The Cancer Genome Atlas, Gene Expression Omnibus and Chinese Glioma Genome Atlas databases were comprehensively analyzed. RESULTS: Low-grade patients had lower expression level of Fn14, while patients with higher expression of Fn14 tended to harbor shorter overall survival and disease-free survival. The expression level of Fn14 was downregulated by IDH1/IDH2 mutations while its gene body methylation was upregulated. After adjusting age, the expression level of Fn14 was still significantly associated with overall survival and disease-free survival in low-grade gliomas. In a cell line data analysis, Fn14 expression was positively correlated with temozolomide dosage. CONCLUSION: Fn14 was an independent predictive biomarker for the progression and prognosis in low-grade gliomas.
AIM: To confirm whether the expression level of Fn14 could affect progression or prognosis of glioma patients. METHODS: Glioma cohorts in The Cancer Genome Atlas, Gene Expression Omnibus and Chinese Glioma Genome Atlas databases were comprehensively analyzed. RESULTS: Low-grade patients had lower expression level of Fn14, while patients with higher expression of Fn14 tended to harbor shorter overall survival and disease-free survival. The expression level of Fn14 was downregulated by IDH1/IDH2 mutations while its gene body methylation was upregulated. After adjusting age, the expression level of Fn14 was still significantly associated with overall survival and disease-free survival in low-grade gliomas. In a cell line data analysis, Fn14 expression was positively correlated with temozolomide dosage. CONCLUSION: Fn14 was an independent predictive biomarker for the progression and prognosis in low-grade gliomas.