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Literature DB >> 29740742

Prospects for engineering dynamic CRISPR-Cas transcriptional circuits to improve bioproduction.

Jason Fontana¹, William E Voje^1,2, Jesse G Zalatan^3,4, James M Carothers^5,6.

Abstract

Dynamic control of gene expression is emerging as an important strategy for controlling flux in metabolic pathways and improving bioproduction of valuable compounds. Integrating dynamic genetic control tools with CRISPR-Cas transcriptional regulation could significantly improve our ability to fine-tune the expression of multiple endogenous and heterologous genes according to the state of the cell. In this mini-review, we combine an analysis of recent literature with examples from our own work to discuss the prospects and challenges of developing dynamically regulated CRISPR-Cas transcriptional control systems for applications in synthetic biology and metabolic engineering.

Keywords: Biosensors; CRISPR–Cas; Dynamic control; Metabolic engineering; Transcriptional control

Mesh：

Substances：
Transcription Factors

Year: 2018 PMID： 29740742 DOI： 10.1007/s10295-018-2039-z

Source DB: PubMed Journal: J Ind Microbiol Biotechnol ISSN： 1367-5435 Impact factor: 3.346

73 in total

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Authors: James M Carothers; Jonathan A Goler; Darmawi Juminaga; Jay D Keasling
Journal: Science Date: 2011-12-23 Impact factor: 47.728

Review 2. Manufacturing molecules through metabolic engineering.

Authors: Jay D Keasling
Journal: Science Date: 2010-12-03 Impact factor: 47.728

3. Engineering static and dynamic control of synthetic pathways.

Authors: William J Holtz; Jay D Keasling
Journal: Cell Date: 2010-01-08 Impact factor: 41.582

4. Employing a combinatorial expression approach to characterize xylose utilization in Saccharomyces cerevisiae.

Authors: Luke N Latimer; Michael E Lee; Daniel Medina-Cleghorn; Rebecca A Kohnz; Daniel K Nomura; John E Dueber
Journal: Metab Eng Date: 2014-06-13 Impact factor: 9.783

5. Design and Construction of Generalizable RNA-Protein Hybrid Controllers by Level-Matched Genetic Signal Amplification.

Authors: Yen-Hsiang Wang; Maureen McKeague; Tammy M Hsu; Christina D Smolke
Journal: Cell Syst Date: 2016-11-10 Impact factor: 10.304

6. Automated physics-based design of synthetic riboswitches from diverse RNA aptamers.

Authors: Amin Espah Borujeni; Dennis M Mishler; Jingzhi Wang; Walker Huso; Howard M Salis
Journal: Nucleic Acids Res Date: 2015-11-30 Impact factor: 16.971

7. Multiplexed and programmable regulation of gene networks with an integrated RNA and CRISPR/Cas toolkit in human cells.

Authors: Lior Nissim; Samuel D Perli; Alexandra Fridkin; Pablo Perez-Pinera; Timothy K Lu
Journal: Mol Cell Date: 2014-05-15 Impact factor: 17.970

8. Synthesis of Morphinan Alkaloids in Saccharomyces cerevisiae.

Authors: Elena Fossati; Lauren Narcross; Andrew Ekins; Jean-Pierre Falgueyret; Vincent J J Martin
Journal: PLoS One Date: 2015-04-23 Impact factor: 3.240

9. Tunable protein degradation in bacteria.

Authors: D Ewen Cameron; James J Collins
Journal: Nat Biotechnol Date: 2014-11-17 Impact factor: 54.908

10. Enhancing flavonoid production by systematically tuning the central metabolic pathways based on a CRISPR interference system in Escherichia coli.

Authors: Junjun Wu; Guocheng Du; Jian Chen; Jingwen Zhou
Journal: Sci Rep Date: 2015-09-01 Impact factor: 4.379

3 in total