Literature DB >> 2974013

Increased methotrexate-induced chromosome breakage in patients with free trisomy 21 and their parents.

L Pelz1, J Götz, G Krüger, G Witt.   

Abstract

Increased susceptibility of chromosomes from peripheral blood lymphocytes to the antimetabolite methotrexate (2 X 10(-6) M) has been found in patients with free trisomy 21 and their parents (N = 14). The level of induced chromatid and chromosome breaks is lowest in normal controls intermediate in patients' mothers and fathers, and highest in trisomy 21 patients. The findings are viewed as a special type of cytogenetic polymorphism or as a defective chromosomal infrastructure, also in the parents of trisomic children.

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Year:  1988        PMID： 2974013     DOI： 10.1007/bf00283726

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  11 in total

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Journal:  Ann Hum Genet       Date:  1976-01       Impact factor: 1.670

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Authors:  M S Sasaki; A Tonomura; S Matsubara
Journal:  Mutat Res       Date:  1970-12       Impact factor: 2.433

5.  Evidence for genetic control of nondisjunction in man.

Authors:  O S Alfi; R Chang; S P Azen
Journal:  Am J Hum Genet       Date:  1980-07       Impact factor: 11.025

6.  Different sensitivity of diploid and trisomic cells from patients with Down syndrome mosaic after treatment with the trifunctional alkylating agent trenimon.

Authors:  P Aldenhoff; R D Wegner; K Sperling
Journal:  Hum Genet       Date:  1980       Impact factor: 4.132

7.  [Mutations induced in vitro by an alkylating agent (zitostop) in malignant diseases and in syndromes predisposing to malignancy].

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Journal:  Humangenetik       Date:  1972

8.  The action of N-methyl-N-nitrosourea on non-established human cell lines in vitro. II. Non-random distribution of chromatid aberrations in diploid and Down's cells.

Authors:  B Kaina
Journal:  Mutat Res       Date:  1977-06       Impact factor: 2.433

9.  The action of N-methyl-N-nitrosourea on non-established human cell lines in vitro. I. Cell cycle inhibition and aberration induction in diploid and Down's fibroblasts.

Authors:  B Kaina; H Waller; M Waller; R Rieger
Journal:  Mutat Res       Date:  1977-06       Impact factor: 2.433

10.  Down syndrome and leukemia: unusual clinical aspects and unexpected methotrexate sensitivity.

Authors:  M Peeters; A Poon
Journal:  Eur J Pediatr       Date:  1987-07       Impact factor: 3.183
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  1 in total

1.  Methotrexate induced apoptotic and necrotic chromatin changes in rat myeloid leukemia cells.

Authors:  Gyorgy Trencsenyi; Fruzsina Bako; Gabor Nagy; Pal Kertai; Gaspar Banfalvi
Journal:  Inflamm Res       Date:  2015-02-12       Impact factor: 4.575
  1 in total

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