Literature DB >> 2973991

Effects of the chitin synthetase inhibitor plumbagin and its 2-demethyl derivative juglone on insect ecdysone 20-monooxygenase activity.

M J Mitchell1, S L Smith.   

Abstract

The chitin synthetase inhibitor plumbagin and its 2-demethyl derivative juglone were found to inhibit in a dose-response fashion the cytochrome P-450 dependent ecdysone 20-monooxygenase activity associated with adult female Aedes aegypti, wandering stage larvae of Drosophila melanogaster, and fat body and midgut from last instar larvae of Manduca sexta. The concentration of these naphthoquinones required to elicit a 50% inhibition of the steroid hydroxylase activity in all the insects was approximately 1 x 10(-4) M.

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Year:  1988        PMID： 2973991     DOI： 10.1007/bf01939896

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  7 in total

1.  Ecdysterone biosynthesis: a microsomal cytochrome-P-450-linked ecdysone 20-monooxygenase from tissues of the African migratory locust.

Authors:  R Feyereisen; F Durst
Journal:  Eur J Biochem       Date:  1978-07-17

2.  Chemosensory mechanism in Periplaneta americana: electroantennogram comparisons of certain quinone feeding inhibitors.

Authors:  D M Norris; H M Chu
Journal:  J Insect Physiol       Date:  1974-09       Impact factor: 2.354

3.  Effects of feeding-inhibitory quinones on the nervous system of Periplaneta.

Authors:  J E Baker; D M Norris
Journal:  Experientia       Date:  1972-01-15

4.  Ecdysone 20-monooxygenase activity during larval-pupal development of Manduca sexta.

Authors:  S L Smith; W E Bollenbacher; L I Gilbert
Journal:  Mol Cell Endocrinol       Date:  1983-08       Impact factor: 4.102

5.  The effect of alpha-ecdysone and phenobarbital on the alpha-ecdysone 20-monooxygenase of house fly larva.

Authors:  J Srivatsan; T Kuwahara; M Agosin
Journal:  Biochem Biophys Res Commun       Date:  1987-11-13       Impact factor: 3.575

6.  The mechanism of C-20 hydroxylation of alpha-ecdysone in the desert locust, Schistocerca gregaria.

Authors:  P Johnson; H H Rees
Journal:  Biochem J       Date:  1977-12-15       Impact factor: 3.857

7.  Ecdysone-mediated stimulation of DOPA decarboxylase activity and its relationship to ovarian development in Aedes aegypti.

Authors:  D A Schlaeger; M S Fuchs; S H Kang
Journal:  J Cell Biol       Date:  1974-05       Impact factor: 10.539
  7 in total
  4 in total

Review 1.  Compounds active against cell walls of medically important fungi.

Authors:  R F Hector
Journal:  Clin Microbiol Rev       Date:  1993-01       Impact factor: 26.132

2.  Differential toxicity of juglone (5-hydroxy-1,4-naphthoquinone) and related naphthoquinones to saturniid moths.

Authors:  R L Thiboldeaux; R L Lindroth; J W Tracy
Journal:  J Chem Ecol       Date:  1994-07       Impact factor: 2.626

3.  Plumbagin, a Potent Naphthoquinone from Nepenthes Plants with Growth Inhibiting and Larvicidal Activities.

Authors:  Asifur Rahman-Soad; Alberto Dávila-Lara; Christian Paetz; Axel Mithöfer
Journal:  Molecules       Date:  2021-02-05       Impact factor: 4.411

Review 4.  Biosynthesis and molecular actions of specialized 1,4-naphthoquinone natural products produced by horticultural plants.

Authors:  Joshua R Widhalm; David Rhodes
Journal:  Hortic Res       Date:  2016-09-21       Impact factor: 6.793
  4 in total

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