PURPOSE: To present a case of bilateral, asymmetric keratoconus presenting unilaterally after partial thyroidectomy with delayed presentation in the second eye after thyrotoxicosis, with disease stabilization following corneal cross-linking (CXL). METHODS: Case report and literature review. RESULTS: A 17-year-old girl with a history of Graves' disease underwent partial thyroidectomy without thyroid hormone replacement therapy with normal baseline ophthalmic examination of corrected distance visual acuity (CDVA) of 20/20 and no manifest astigmatism in either eye. At age 29 years, keratoconus manifested in the right eye and standard protocol CXL was performed. At age 40 years, the right eye remained stable after CXL, but keratoconus manifested in the left eye and epithelium-off accelerated CXL was performed with subsequent disease stabilization. CONCLUSIONS: This case demonstrates the association between thyrotoxicosis and keratoconus and the bilateral nature of keratoconus, and highlights the potentially asymmetric presentation of thyroid-induced keratoconus. CXL had a long-term stabilizing effect over 10 years despite the ongoing effects of thyroid gland dysfunction. [J Refract Surg. 2018;34(5):354-356.]. Copyright 2018, SLACK Incorporated.
PURPOSE: To present a case of bilateral, asymmetric keratoconus presenting unilaterally after partial thyroidectomy with delayed presentation in the second eye after thyrotoxicosis, with disease stabilization following corneal cross-linking (CXL). METHODS: Case report and literature review. RESULTS: A 17-year-old girl with a history of Graves' disease underwent partial thyroidectomy without thyroid hormone replacement therapy with normal baseline ophthalmic examination of corrected distance visual acuity (CDVA) of 20/20 and no manifest astigmatism in either eye. At age 29 years, keratoconus manifested in the right eye and standard protocol CXL was performed. At age 40 years, the right eye remained stable after CXL, but keratoconus manifested in the left eye and epithelium-off accelerated CXL was performed with subsequent disease stabilization. CONCLUSIONS: This case demonstrates the association between thyrotoxicosis and keratoconus and the bilateral nature of keratoconus, and highlights the potentially asymmetric presentation of thyroid-induced keratoconus. CXL had a long-term stabilizing effect over 10 years despite the ongoing effects of thyroid gland dysfunction. [J Refract Surg. 2018;34(5):354-356.]. Copyright 2018, SLACK Incorporated.