Literature DB >> 29738243

Antiplasmodial Diterpenoids and a Benzotropolone from Petradoria pumila.

Yongle Du1, Ana L Valenciano2, Michael Goetz3, Maria B Cassera2, David G I Kingston1.   

Abstract

An extract of Petradoria pumila from the Natural Products Discovery Institute was found to have moderate antiplasmodial activity, with an IC50 value between 5 and 10 μg/mL. The four new diterpenoids petradoriolides A-D (1-4), the new benzotropolone petradoriolone (5), and the two known lignans 6 and 7 were isolated after bioassay-directed fractionation. The structures and stereochemistries of the new compounds were determined by interpretation of NMR spectroscopy, mass spectrometry, and ECD spectra. Among these compounds, petradoriolide C (3) displayed the most potent antiplasmodial activity, with an IC50 value of 7.3 μM.

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Year:  2018        PMID： 29738243      PMCID： PMC7025711          DOI： 10.1021/acs.jnatprod.8b00135

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  13 in total

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  2 in total

1.  Galtonosides A-E: Antiproliferative and Antiplasmodial Cholestane Glycosides from Galtonia regalis.

Authors:  Yongle Du; Brooke A Martin; Ana Lisa Valenciano; Jason A Clement; Michael Goetz; Maria B Cassera; David G I Kingston
Journal:  J Nat Prod       Date:  2020-03-31       Impact factor: 4.050

Review 2.  Antimicrobial Diterpenes: Recent Development From Natural Sources.

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