Leping Fan1, Yue Zhang1, Jie Zhu1, Yixuan Song1, Jingna Lin2. 1. Department of Endocrinology, Tianjin Union Medical Center, Tianjin, China. 2. Department of Endocrinology, Tianjin Union Medical Center, Tianjin, China. 13207628978 @163.com.
Abstract
BACKGROUND AND OBJECTIVES: To evaluate the association of vitamin D deficiency with type 2 diabetic peripheral neuropathy (DPN) and diabetic nephropathy (DN). METHODS AND STUDY DESIGN: A total of 287 type 2 diabetic patients were categorized in two ways, and each divided into two groups: DPN (n=164) and non-DPN (NDPN) groups (n=123); and DN (n=148) and non-DN (NDN) groups (n=139). Enzyme-linked immunosorbent assay was used to measure the 25-hydroxy vitamin D [25(OH)D3] level. Correlation analysis between 25(OH)D3 and other indicators was performed. RESULTS: 25(OH)D3 levels were lower in the DPN and DN groups than in the NDPN and NDN groups, and the difference was statistically significant (t =-6.23, -4.38, p<0.0001). Moreover, a higher proportion of patients in the DPN and DN groups exhibited vitamin D deficiency than those in the NDPN and NDN groups (χ2=22.231, 15.973, respectively, p<0.0001). Vitamin D was highly correlated with DPN, DN, diabetes duration, age, sex, fasting plasma glucose, blood urea nitrogen, total cholesterol, low density lipoprotein cholesterol, 24-h urinary microalbumin, and beta-2 microglobulin (r=-0.34 ~ -0.133, p<0.05). Binary logistic regression analysis revealed that vitamin D deficiency is an independent risk factor for DPN and DN (OR=3.53, 95% confidence interval [CI]: 2.06-6.03; OR=2.93, 95% CI: 1.71-5.03; respectively, p<0.0001). CONCLUSIONS: Vitamin D deficiency is closely correlated with DPN and DN and can be considered as an independent risk factor for DPN and DN.
BACKGROUND AND OBJECTIVES: To evaluate the association of vitamin D deficiency with type 2 diabetic peripheral neuropathy (DPN) and diabetic nephropathy (DN). METHODS AND STUDY DESIGN: A total of 287 type 2 diabeticpatients were categorized in two ways, and each divided into two groups: DPN (n=164) and non-DPN (NDPN) groups (n=123); and DN (n=148) and non-DN (NDN) groups (n=139). Enzyme-linked immunosorbent assay was used to measure the 25-hydroxy vitamin D [25(OH)D3] level. Correlation analysis between 25(OH)D3 and other indicators was performed. RESULTS:25(OH)D3 levels were lower in the DPN and DN groups than in the NDPN and NDN groups, and the difference was statistically significant (t =-6.23, -4.38, p<0.0001). Moreover, a higher proportion of patients in the DPN and DN groups exhibited vitamin D deficiency than those in the NDPN and NDN groups (χ2=22.231, 15.973, respectively, p<0.0001). Vitamin D was highly correlated with DPN, DN, diabetes duration, age, sex, fasting plasma glucose, blood ureanitrogen, total cholesterol, low density lipoprotein cholesterol, 24-h urinary microalbumin, and beta-2 microglobulin (r=-0.34 ~ -0.133, p<0.05). Binary logistic regression analysis revealed that vitamin D deficiency is an independent risk factor for DPN and DN (OR=3.53, 95% confidence interval [CI]: 2.06-6.03; OR=2.93, 95% CI: 1.71-5.03; respectively, p<0.0001). CONCLUSIONS:Vitamin D deficiency is closely correlated with DPN and DN and can be considered as an independent risk factor for DPN and DN.
Authors: Dan Ziegler; Barbara Thorand; Haifa Maalmi; Christian Herder; Cornelia Huth; Wolfgang Rathmann; Gidon J Bönhof; Margit Heier; Wolfgang Koenig; Michael Roden; Annette Peters Journal: Int J Obes (Lond) Date: 2022-04-26 Impact factor: 5.551