Literature DB >> 2973756

Failure of a dengue 1 sub-unit vaccine to protect mice against a lethal dengue virus infection.

J G Aaskov1, L Williams, J Fletcher, R Hay.   

Abstract

Mice immunized with DEN-1 pre-matrix protein produced antibody which reacted with dengue virus infected cells and intact virions but failed to neutralize virus in vitro or in vivo. Newborn mice passively immunized with anti-DEN-1 pre-matrix antibody also failed to survive intracerebral infection with 100 LD50 of any dengue virus serotype.

Entities:  

Mesh:

Substances:

Year:  1988        PMID: 2973756     DOI: 10.4269/ajtmh.1988.39.511

Source DB:  PubMed          Journal:  Am J Trop Med Hyg        ISSN: 0002-9637            Impact factor:   2.345


  2 in total

1.  Analysis of functional epitopes on the dengue 2 envelope (E) protein using monoclonal IgM antibodies.

Authors:  Z Jianmin; M L Linn; R Bulich; M K Gentry; J G Aaskov
Journal:  Arch Virol       Date:  1995       Impact factor: 2.574

Review 2.  Antibody-mediated neutralization of flaviviruses: a reductionist view.

Authors:  Kimberly A Dowd; Theodore C Pierson
Journal:  Virology       Date:  2011-01-20       Impact factor: 3.616

  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.