Brianna N VanNoy1, Juleen Lam2, Ami R Zota3. 1. Department of Environmental and Occupational Health, The George Washington University Milken Institute School of Public Health, 950 New Hampshire Ave NW, Suite 400, Washington, DC, 20052, USA. 2. Program on Reproductive Health and the Environment, Department of OB/GYN and Reproductive Sciences, University of California, San Francisco, CA, USA. 3. Department of Environmental and Occupational Health, The George Washington University Milken Institute School of Public Health, 950 New Hampshire Ave NW, Suite 400, Washington, DC, 20052, USA. azota@gwu.edu.
Abstract
PURPOSE OF REVIEW: Per- and polyfluorinated alkyl substances (PFASs) are synthetic chemicals widely detected in human serum, and at low levels in breast milk. We conducted a rapid systematic review on breastfeeding practices and serum concentrations of PFASs-specifically PFOS and PFOA-among reproductive-aged women and young children using the Navigation Guide systematic review methodology. RECENT FINDINGS: We included 14 studies examining associations between breastfeeding and PFASs in infants/toddlers or pregnant/postnatal women. Breastfeeding was significantly associated with lower PFASs exposure among women and higher PFASs exposure among children. We concluded there was "sufficient" evidence supporting an association between breastfeeding and serum PFASs concentrations among women, and "limited" evidence of an association among children due to issues with sample size, confounding, and exposure assessment. These findings reinforce that lactation is an important excretion route of PFASs for women, and that breast milk may be an important exposure pathway for young children.
PURPOSE OF REVIEW: Per- and polyfluorinated alkyl substances (PFASs) are synthetic chemicals widely detected in human serum, and at low levels in breast milk. We conducted a rapid systematic review on breastfeeding practices and serum concentrations of PFASs-specifically PFOS and PFOA-among reproductive-aged women and young children using the Navigation Guide systematic review methodology. RECENT FINDINGS: We included 14 studies examining associations between breastfeeding and PFASs in infants/toddlers or pregnant/postnatal women. Breastfeeding was significantly associated with lower PFASs exposure among women and higher PFASs exposure among children. We concluded there was "sufficient" evidence supporting an association between breastfeeding and serum PFASs concentrations among women, and "limited" evidence of an association among children due to issues with sample size, confounding, and exposure assessment. These findings reinforce that lactation is an important excretion route of PFASs for women, and that breast milk may be an important exposure pathway for young children.
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