Hannah Myles1, Andrew Vincent2, Nicholas Myles3, Robert Adams4, Madhu Chandratilleke5, Dennis Liu6, Jeremy Mercer5, Andrew Vakulin7, Gary Wittert8, Cherrie Galletly9. 1. Discipline of Psychiatry, University of Adelaide, Adelaide, SA, and; Country Health (SA) Mental Health; Northern Adelaide Local Health Network, Adelaide, SA, Australia. 2. School of Medicine, University of Adelaide, Adelaide, SA, and; Freemasons Foundation Centre for Men's Health, University of Adelaide, Adelaide, SA, Australia. 3. School of Medicine, University of Queensland, Herston, QLD, and; Haematology Directorate, SA Pathology, Adelaide, SA, Australia. 4. School of Medicine, University of Adelaide, and; The Health Observatory, Discipline of Medicine, The Queen Elizabeth Hospital, Adelaide, SA, Australia. 5. Adelaide Institute for Sleep Health: A Flinders Centre for Research Excellence, Flinders University, Daw Park, SA, Australia. 6. Discipline of Psychiatry, The University of Adelaide, Adelaide, SA, and; Northern Adelaide Local Health Network, Adelaide, SA, Australia. 7. NeuroSleep and Woolcock Institute of Medical Research, University of Sydney, Sydney, NSW, and; Adelaide Institute for Sleep Health: A Flinders Centre for Research Excellence, Flinders University, Daw Park, SA, Australia. 8. School of Medicine, University of Adelaide, and; Freemasons Foundation Centre for Men's Health, University of Adelaide, Australia. 9. Discipline of Psychiatry, University of Adelaide, Adelaide, SA, and; Ramsay Health Care (SA) Mental Health, Adelaide, SA, and; Northern Adelaide Local Health Network, Adelaide, SA, Australia.
Abstract
OBJECTIVES: : Obstructive sleep apnoea (OSA) may be more common in people with schizophrenia compared to the general population, but the relative prevalence is unknown. Here, we determine the relative prevalence of severe OSA in a cohort of men with schizophrenia compared to representative general population controls, and investigate the contribution of age and body mass index (BMI) to differences in prevalence. METHODS: : Rates of severe OSA (apnoea-hypopnoea index > 30) were compared between male patients with schizophrenia and controls from a representative general population study of OSA. RESULTS: : The prevalence of severe OSA was 25% in the schizophrenia group and 12.3% in the general population group. In subgroups matched by age, the relative risk of severe OSA was 2.9 ( p = 0.05) in the schizophrenia subjects, but when adjusted for age and BMI, the relative risk dropped to 1.7 and became non-significant ( p = 0.17). CONCLUSIONS: : OSA is prevalent in men with schizophrenia. Obesity may be an important contributing factor to the increased rate of OSA.
OBJECTIVES: : Obstructive sleep apnoea (OSA) may be more common in people with schizophrenia compared to the general population, but the relative prevalence is unknown. Here, we determine the relative prevalence of severe OSA in a cohort of men with schizophrenia compared to representative general population controls, and investigate the contribution of age and body mass index (BMI) to differences in prevalence. METHODS: : Rates of severe OSA (apnoea-hypopnoea index > 30) were compared between male patients with schizophrenia and controls from a representative general population study of OSA. RESULTS: : The prevalence of severe OSA was 25% in the schizophrenia group and 12.3% in the general population group. In subgroups matched by age, the relative risk of severe OSA was 2.9 ( p = 0.05) in the schizophrenia subjects, but when adjusted for age and BMI, the relative risk dropped to 1.7 and became non-significant ( p = 0.17). CONCLUSIONS: : OSA is prevalent in men with schizophrenia. Obesity may be an important contributing factor to the increased rate of OSA.
Authors: Hannah Myles; Nicholas Myles; Ching Li Chai Coetzer; Robert Adams; Madhu Chandratilleke; Dennis Liu; Jeremy Mercer; Andrew Vakulin; Andrew Vincent; Gary Wittert; Cherrie Galletly Journal: Schizophr Res Cogn Date: 2018-11-06