Literature DB >> 2973565

Interaction at a distance between lambda repressors disrupts gene activation.

A Hochschild1, M Ptashne.   

Abstract

The lambda repressor is an activator as well as a repressor of transcription. The activation function is blocked by interaction with another lambda repressor molecule bound upstream on the same DNA molecule. This example of negative control at a distance involves formation of a DNA loop.

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Year:  1988        PMID： 2973565     DOI： 10.1038/336353a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  25 in total

1.  Octamerization of lambda CI repressor is needed for effective repression of P(RM) and efficient switching from lysogeny.

Authors:  I B Dodd; A J Perkins; D Tsemitsidis; J B Egan
Journal:  Genes Dev       Date:  2001-11-15       Impact factor: 11.361

2.  DeoR repression at-a-distance only weakly responds to changes in interoperator separation and DNA topology.

Authors:  G Dandanell
Journal:  Nucleic Acids Res       Date:  1992-10-25       Impact factor: 16.971

3.  Purification and characterization of the repressor of the shiga toxin-encoding bacteriophage 933W: DNA binding, gene regulation, and autocleavage.

Authors:  Astrid P Koudelka; Lisa A Hufnagel; Gerald B Koudelka
Journal:  J Bacteriol       Date:  2004-11       Impact factor: 3.490

Review 4.  DNA looping.

Authors:  K S Matthews
Journal:  Microbiol Rev       Date:  1992-03

5.  Activating regions of yeast transcription factors must have both acidic and hydrophobic amino acids.

Authors:  D M Ruden
Journal:  Chromosoma       Date:  1992-03       Impact factor: 4.316

Review 6.  Transcriptional regulation by the numbers: models.

Authors:  Lacramioara Bintu; Nicolas E Buchler; Hernan G Garcia; Ulrich Gerland; Terence Hwa; Jané Kondev; Rob Phillips
Journal:  Curr Opin Genet Dev       Date:  2005-04       Impact factor: 5.578

7.  Transcription in vivo within the replication origin of the Escherichia coli chromosome: a mechanism for activating initiation of replication.

Authors:  T Asai; C P Chen; T Nagata; M Takanami; M Imai
Journal:  Mol Gen Genet       Date:  1992-01

8.  Biochemistry on a leash: the roles of tether length and geometry in signal integration proteins.

Authors:  David Van Valen; Mikko Haataja; Rob Phillips
Journal:  Biophys J       Date:  2009-02-18       Impact factor: 4.033

9.  AbrB, a regulator of gene expression in Bacillus, interacts with the transcription initiation regions of a sporulation gene and an antibiotic biosynthesis gene.

Authors:  J B Robertson; M Gocht; M A Marahiel; P Zuber
Journal:  Proc Natl Acad Sci U S A       Date:  1989-11       Impact factor: 11.205

10.  Synergistic activation of transcription by Escherichia coli cAMP receptor protein.

Authors:  J K Joung; L U Le; A Hochschild
Journal:  Proc Natl Acad Sci U S A       Date:  1993-04-01       Impact factor: 11.205
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