Literature DB >> 2973434

Alterations in helper-inducer and suppressor-inducer T-cell subsets in human neonatal blood.

R Landesberg1, M Fallon, R Insel.   

Abstract

The distribution of T-helper cell subsets of human umbilical cord lymphocytes was compared with that of adult peripheral blood lymphocytes. Cytofluorometric analysis revealed a similar Leu 3/Leu 2 (helper/suppressor) ratio in neonates compared with adults. Total T-cell numbers were slightly decreased in neonatal blood. The Leu 3-positive-4B4-positive cell (helper-inducer) subset, however, was markedly reduced in neonatal blood, while the Leu 3-positive-2H4-positive cell (suppressor-inducer) subset was increased compared with that of normal adults. These findings may contribute to the poor help and enhanced suppression observed in vitro with neonatal T cells.

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Year:  1988        PMID： 2973434      PMCID： PMC1384933     

Source DB:  PubMed          Journal:  Immunology        ISSN： 0019-2805            Impact factor:   7.397


  12 in total

1.  Induction of plasma cell differentiation of human fetal lymphocytes: evidence for functional immaturity of T and B cells.

Authors:  A R Hayward; A R Lawton
Journal:  J Immunol       Date:  1977-10       Impact factor: 5.422

2.  The role of the 2H4 molecule in the generation of suppressor function in Con A-activated T cells.

Authors:  C Morimoto; N L Letvin; C E Rudd; M Hagan; T Takeuchi; S F Schlossman
Journal:  J Immunol       Date:  1986-11-15       Impact factor: 5.422

3.  Immunofluorescent studies of the development of pre-B cells, B lymphocytes and immunoglobulin isotype diversity in humans.

Authors:  W E Gathings; A R Lawton; M D Cooper
Journal:  Eur J Immunol       Date:  1977-11       Impact factor: 5.532

4.  Characterization of immature T cell subpopulations in neonatal blood.

Authors:  S Griffiths-Chu; J A Patterson; C L Berger; R L Edelson; A C Chu
Journal:  Blood       Date:  1984-07       Impact factor: 22.113

Review 5.  Functional aspects of IgM and IgG Fc receptors on murine T lymphocytes.

Authors:  B Andersson; A C Skoglund; M Rönnholm; T Lindsten; E W Lamon; E W Collisson; A S Walia
Journal:  Immunol Rev       Date:  1981       Impact factor: 12.988

6.  B cell differentiation and immunoregulatory T cell function in human cord blood lymphocytes.

Authors:  G Tosato; I T Magrath; I R Koski; N J Dooley; R M Blaese
Journal:  J Clin Invest       Date:  1980-08       Impact factor: 14.808

7.  Studies of human cord blood and adult lymphocyte interactions with in vitro immunoglobulin production.

Authors:  T Morito; A D Bankhurst; R C Williams
Journal:  J Clin Invest       Date:  1979-10       Impact factor: 14.808

8.  Human lymphocyte differentiation antigens HB-10 and HB-11. II. Differential production of B cell growth and differentiation factors by distinct helper T cell subpopulations.

Authors:  T F Tedder; M D Cooper; L T Clement
Journal:  J Immunol       Date:  1985-05       Impact factor: 5.422

9.  Human lymphocyte differentiation antigens HB-10 and HB-11. I. Ontogeny of antigen expression.

Authors:  T F Tedder; L T Clement; M D Cooper
Journal:  J Immunol       Date:  1985-05       Impact factor: 5.422

10.  The isolation and characterization of the human suppressor inducer T cell subset.

Authors:  C Morimoto; N L Letvin; J A Distaso; W R Aldrich; S F Schlossman
Journal:  J Immunol       Date:  1985-03       Impact factor: 5.422
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  4 in total

1.  Selective deficiency of CD4+/CD45RA+ lymphocytes in patients with ataxia-telangiectasia.

Authors:  R Paganelli; E Scala; E Scarselli; C Ortolani; A Cossarizza; D Carmini; F Aiuti; M Fiorilli
Journal:  J Clin Immunol       Date:  1992-03       Impact factor: 8.317

2.  Immunoregulatory CD4+ CD45R+ suppressor/inducer T lymphocyte subsets and impaired cell-mediated immunity in patients with Down's syndrome.

Authors:  S Raziuddin; M E Elawad
Journal:  Clin Exp Immunol       Date:  1990-01       Impact factor: 4.330

3.  Th1/Th2 patterns and balance in cytokine production in the parents and infants of a large birth cohort.

Authors:  Marilyn Halonen; I Carla Lohman; Debra A Stern; Amber Spangenberg; Dayna Anderson; Sara Mobley; Kathy Ciano; Michael Peck; Anne L Wright
Journal:  J Immunol       Date:  2009-03-01       Impact factor: 5.422

4.  Immunoglobulin and cytokine production by neonatal lymphocytes.

Authors:  W Watson; K Oen; R Ramdahin; C Harman
Journal:  Clin Exp Immunol       Date:  1991-01       Impact factor: 4.330
  4 in total

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