Literature DB >> 29733293

A viral protein kinase drug target for tumors?

Richard F Ambinder.   

Abstract

The human gammaherpesviruses, Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV), are both associated with tumors. Standard antiviral therapies are ineffective at treating these tumors. A serine/threonine kinase important for viral replication is conserved across the herpesviruses. Expression of the KSHV protein kinase in transgenic mice under the control of a ubiquitin promoter was associated with B cell lymphoproliferative disease and lymphoma. If the viral protein kinase is important in the pathogenesis of KSHV lymphoproliferative disease or lymphoma, the kinase may present a very good target for pharmacologic therapies.

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Year:  2018        PMID： 29733293      PMCID： PMC5983323          DOI： 10.1172/JCI121080

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  8 in total

1.  Human herpesvirus-encoded kinase induces B cell lymphomas in vivo.

Authors:  Penny M Anders; Nathan D Montgomery; Stephanie A Montgomery; Aadra P Bhatt; Dirk P Dittmer; Blossom Damania
Journal:  J Clin Invest       Date:  2018-05-07       Impact factor: 14.808

2.  Conserved herpesvirus kinases target the DNA damage response pathway and TIP60 histone acetyltransferase to promote virus replication.

Authors:  Renfeng Li; Jian Zhu; Zhi Xie; Gangling Liao; Jianyong Liu; Mei-Ru Chen; Shaohui Hu; Crystal Woodard; Jimmy Lin; Sean D Taverna; Prashant Desai; Richard F Ambinder; Gary S Hayward; Jiang Qian; Heng Zhu; S Diane Hayward
Journal:  Cell Host Microbe       Date:  2011-10-20       Impact factor: 21.023

Review 3.  Gammaherpesviruses and lymphoproliferative disorders.

Authors:  Ethel Cesarman
Journal:  Annu Rev Pathol       Date:  2013-10-09       Impact factor: 23.472

4.  Human cytomegalovirus UL97 phosphorylates the viral nuclear egress complex.

Authors:  Mayuri Sharma; Brian J Bender; Jeremy P Kamil; Ming F Lye; Jean M Pesola; Natalia I Reim; James M Hogle; Donald M Coen
Journal:  J Virol       Date:  2014-10-22       Impact factor: 5.103

5.  Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) contains hypoxia response elements: relevance to lytic induction by hypoxia.

Authors:  Muzammel Haque; David A Davis; Victoria Wang; Isabelle Widmer; Robert Yarchoan
Journal:  J Virol       Date:  2003-06       Impact factor: 5.103

Review 6.  Epstein-Barr virus: more than 50 years old and still providing surprises.

Authors:  Lawrence S Young; Lee Fah Yap; Paul G Murray
Journal:  Nat Rev Cancer       Date:  2016-09-30       Impact factor: 60.716

7.  Hypoxia enhances the phosphorylation and cytotoxicity of ganciclovir and zidovudine in Kaposi's sarcoma-associated herpesvirus infected cells.

Authors:  David A Davis; Kathleen E Singer; Irene P Reynolds; Muzammel Haque; Robert Yarchoan
Journal:  Cancer Res       Date:  2007-07-15       Impact factor: 12.701

8.  Computational analysis of EBNA1 "druggability" suggests novel insights for Epstein-Barr virus inhibitor design.

Authors:  Eleonora Gianti; Troy E Messick; Paul M Lieberman; Randy J Zauhar
Journal:  J Comput Aided Mol Des       Date:  2016-04-05       Impact factor: 3.686
  8 in total
  1 in total

1.  Discovery of Hordenine as a Potential Inhibitor of Pyruvate Dehydrogenase Kinase 3: Implication in Lung Cancer Therapy.

Authors:  Saleha Anwar; Taj Mohammad; Anas Shamsi; Aarfa Queen; Shahnaz Parveen; Suaib Luqman; Gulam Mustafa Hasan; Khalid A Alamry; Naved Azum; Abdullah M Asiri; Md Imtaiyaz Hassan
Journal:  Biomedicines       Date:  2020-05-14
  1 in total

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