Literature DB >> 2973313

Cloning of a complete cDNA encoding human aromatase: immunochemical identification and sequence analysis.

N Harada1.   

Abstract

A complete cDNA clone encoding a human aromatase was isolated from a human placental cDNA library in lambda gt11. An antibody to the polypeptide specified by the isolated clone was prepared, and Western blot analysis and antibody inhibition experiments of human placental aromatase activity confirmed the identification of the clone as aromatase cDNA. The isolated aromatase cDNA clone of 3030 bp with two unique EcoRI sites contained a 3'-noncoding region of 1397 bp, an open reading frame of 1509 bp encoding 503 amino acid residues, and a 5'-noncoding region of 124 bp. Analysis of the amino acid sequence of aromatase and comparison of aromatase with other forms of cytochrome P-450 indicated that this enzyme is a unique form of the cytochrome P-450 superfamily.

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Year:  1988        PMID： 2973313     DOI： 10.1016/s0006-291x(88)80903-3

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  14 in total

1.  Birth of neural progenitors during the embryonic period of sexual differentiation in the Japanese quail brain.

Authors:  Sylvia M Bardet; Karen Mouriec; Jacques Balthazart
Journal:  J Comp Neurol       Date:  2012-12-15       Impact factor: 3.215

Review 2.  Impact of estrogens in males and androgens in females.

Authors:  Stephen R Hammes; Ellis R Levin
Journal:  J Clin Invest       Date:  2019-05-01       Impact factor: 14.808

Review 3.  Importance of sex to pain and its amelioration; relevance of spinal estrogens and its membrane receptors.

Authors:  Alan R Gintzler; Nai-Jiang Liu
Journal:  Front Neuroendocrinol       Date:  2012-10-02       Impact factor: 8.606

Review 4.  Behavioral effects of brain-derived estrogens in birds.

Authors:  Jacques Balthazart; Melanie Taziaux; Kevin Holloway; Gregory F Ball; Charlotte A Cornil
Journal:  Ann N Y Acad Sci       Date:  2009-04       Impact factor: 5.691

5.  Structure-function studies of human aromatase by site-directed mutagenesis: kinetic properties of mutants Pro-308----Phe, Tyr-361----Phe, Tyr-361----Leu, and Phe-406----Arg.

Authors:  D J Zhou; D Pompon; S A Chen
Journal:  Proc Natl Acad Sci U S A       Date:  1991-01-15       Impact factor: 11.205

Review 6.  Rapid regulation of brain oestrogen synthesis: the behavioural roles of oestrogens and their fates.

Authors:  C A Cornil
Journal:  J Neuroendocrinol       Date:  2009-01-15       Impact factor: 3.627

7.  Aromatase cytochrome P450 enzyme expression in human pituitary.

Authors:  Pinar Kadioglu; Gokhan Oral; Muge Sayitoglu; Nevin Erensoy; Berna Senel; Nurperi Gazioglu; Aydin Sav; Gursel Cetin; Ugur Ozbek
Journal:  Pituitary       Date:  2008       Impact factor: 4.107

8.  Molecular basis of aromatase deficiency in an adult female with sexual infantilism and polycystic ovaries.

Authors:  Y Ito; C R Fisher; F A Conte; M M Grumbach; E R Simpson
Journal:  Proc Natl Acad Sci U S A       Date:  1993-12-15       Impact factor: 11.205

9.  Tissue-specific expression of the human aromatase cytochrome P-450 gene by alternative use of multiple exons 1 and promoters, and switching of tissue-specific exons 1 in carcinogenesis.

Authors:  N Harada; T Utsumi; Y Takagi
Journal:  Proc Natl Acad Sci U S A       Date:  1993-12-01       Impact factor: 11.205

10.  Rapid estradiol/ERalpha signaling enhances aromatase enzymatic activity in breast cancer cells.

Authors:  Stefania Catalano; Ines Barone; Cinzia Giordano; Pietro Rizza; Hongyan Qi; Guowei Gu; Rocco Malivindi; Daniela Bonofiglio; Sebastiano Andò
Journal:  Mol Endocrinol       Date:  2009-06-25
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