Thankamma Ajithkumar1, Gail Horan2, Laetitia Padovani3, Nicky Thorp4, Beate Timmermann5, Claire Alapetite6, Lorenza Gandola7, Monica Ramos8, Karen Van Beek9, Melissa Christiaens9, Yasmin Lassen-Ramshad10, Henriette Magelssen11, Kristina Nilsson12, Frank Saran13, Barbara Rombi14, Rolf Kortmann15, Geert O Janssens16. 1. Department of Oncology, Cambridge University Hospitals, United Kingdom. Electronic address: Thankamma.ajithkumar@addenbrookes.nhs.uk. 2. Department of Oncology, Cambridge University Hospitals, United Kingdom. 3. Department of Radiation Oncology, Assistance Publique Hôpitaux de Marseille, France. 4. Department of Oncology, Clatterbridge Cancer Centre, Liverpool, United Kingdom. 5. West German Proton Centre, University of Essen, Germany. 6. Radiation Oncology department and Proton Centre, Institute Curie, Paris and Orsay, France. 7. Department of Radiation Oncology, Fondazione IRCCS-Istituto Nazionale dei Tumori, Milan, Italy. 8. Hospital Universitari de la Vall d'Hebron, Barcelona, Spain. 9. Radiotherapie-Oncologie, UZ Leuven, Belgium. 10. Danish Centre for Particle Therapy, Aarhus University Hospital, Denmark. 11. Department of Oncology, Oslo University Hospital (The Norwegian Radium Hospital), Norway. 12. Department of Immunology, Genetics and Pathology, Experimental and Clinical Oncology, Clinical Oncology, Uppsala University Hospital, Sweden. 13. Department of Oncology, Royal Marsden Hospital, Sutton, United Kingdom. 14. Proton Therapy Center, Santa Chiara Hospital, Trento, Italy. 15. Department of Radiation Oncology, University of Leipzig, Germany. 16. Department of Radiation Oncology, University Medical Center Utrecht, and Princess Maxima Center for Pediatric Oncology, The Netherlands.
Abstract
OBJECTIVE: To develop a consensus guideline for craniospinal target volume (TV) delineation in children and young adults participating in SIOPE studies in the era of high-precision radiotherapy. METHODS AND MATERIALS: During four consensus meetings (Cambridge, Essen, Liverpool, and Marseille), conventional field-based TV has been translated into image-guided high-precision craniospinal TV by a group of expert paediatric radiation oncologists and enhanced by MRI images of liquor distribution. RESULTS: The CTVcranial should include the whole brain, cribriform plate, most inferior part of the temporal lobes, and the pituitary fossa. If the full length of both optic nerves is not included, the dose received by different volumes of optic nerve should be recorded to correlate with future patterns of relapse (no consensus). The CTVcranial should be modified to include the dural cuffs of cranial nerves as they pass through the skull base foramina. Attempts to spare the cochlea by excluding CSF within the internal auditory canal should be avoided. The CTVspinal should include the entire subarachnoid space, including nerve roots laterally. The lower limit of the spinal CTV is at the lower limit of the thecal sac, best visible on MRI scan. There is no need to include sacral root canals in the spinal CTV. CONCLUSION: This consensus guideline has the potential to improve consistency of craniospinal TV delineation in an era of high-precision radiotherapy. This proposal will be incorporated in the RTQA guidelines of future SIOPE-BTG trials using CSI.
OBJECTIVE: To develop a consensus guideline for craniospinal target volume (TV) delineation in children and young adults participating in SIOPE studies in the era of high-precision radiotherapy. METHODS AND MATERIALS: During four consensus meetings (Cambridge, Essen, Liverpool, and Marseille), conventional field-based TV has been translated into image-guided high-precision craniospinal TV by a group of expert paediatric radiation oncologists and enhanced by MRI images of liquor distribution. RESULTS: The CTVcranial should include the whole brain, cribriform plate, most inferior part of the temporal lobes, and the pituitary fossa. If the full length of both optic nerves is not included, the dose received by different volumes of optic nerve should be recorded to correlate with future patterns of relapse (no consensus). The CTVcranial should be modified to include the dural cuffs of cranial nerves as they pass through the skull base foramina. Attempts to spare the cochlea by excluding CSF within the internal auditory canal should be avoided. The CTVspinal should include the entire subarachnoid space, including nerve roots laterally. The lower limit of the spinal CTV is at the lower limit of the thecal sac, best visible on MRI scan. There is no need to include sacral root canals in the spinal CTV. CONCLUSION: This consensus guideline has the potential to improve consistency of craniospinal TV delineation in an era of high-precision radiotherapy. This proposal will be incorporated in the RTQA guidelines of future SIOPE-BTG trials using CSI.
Authors: Stefan Dietzsch; Annett Braesigk; Clemens Seidel; Julia Remmele; Ralf Kitzing; Tina Schlender; Martin Mynarek; Dirk Geismar; Karolina Jablonska; Rudolf Schwarz; Montserrat Pazos; Marc Walser; Silke Frick; Kristin Gurtner; Christiane Matuschek; Semi Ben Harrabi; Albrecht Glück; Victor Lewitzki; Karin Dieckmann; Martin Benesch; Nicolas U Gerber; Stefan Rutkowski; Beate Timmermann; Rolf-Dieter Kortmann Journal: Strahlenther Onkol Date: 2020-11-23 Impact factor: 3.621
Authors: Gyu Sang Yoo; Jeong Il Yu; Sungkoo Cho; Youngyih Han; Yoonjin Oh; Do Hoon Lim; Hee Rim Nam; Ji-Won Lee; Ki-Woong Sung; Hyung Jin Shin Journal: Cancer Res Treat Date: 2021-10-15 Impact factor: 5.036
Authors: Joeri Mul; Enrica Seravalli; Mirjam E Bosman; Cornelis P van de Ven; Annemieke S Littooij; Martine van Grotel; Marry M van den Heuvel-Eibrink; Geert O Janssens Journal: Clin Transl Radiat Oncol Date: 2021-05-03
Authors: Jennifer Novak; Dongsu Du; Ashwin Shinde; Richard Li; Arya Amini; Yi-Jen Chen; Jeffrey Wong; Chunhui Han; John Neylon; An Liu; Scott Glaser Journal: Adv Radiat Oncol Date: 2021-07-04
Authors: Bianca A W Hoeben; Enrica Seravalli; Amber M L Wood; Mirjam Bosman; Witold P Matysiak; John H Maduro; Astrid L H M W van Lier; Matteo Maspero; Gijsbert H Bol; Geert O Janssens Journal: Clin Transl Radiat Oncol Date: 2021-08-29
Authors: Simon Bailey; Nicolas André; Lorenza Gandola; Maura Massimino; Stefan Rutkowski; Steven C Clifford Journal: Cancers (Basel) Date: 2022-01-13 Impact factor: 6.575