Literature DB >> 29729835

To Scar or Not to Scar.

Aarti Narang1, Binhai Zheng2.   

Abstract

A recent study indicates that reducing fibrotic scarring by genetically abrogating the proliferation of type A pericytes promotes axon regeneration and functional recovery after spinal cord injury. Questions remain regarding the identity of the cells being manipulated and the balance between the beneficial and detrimental effects of fibrotic scarring.
Copyright © 2018 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  astrocytic scar; axon regeneration; fibrotic scar; functional recovery; spinal cord injury

Mesh：

Year:  2018        PMID： 29729835      PMCID： PMC5975241          DOI： 10.1016/j.molmed.2018.04.007

Source DB:  PubMed          Journal:  Trends Mol Med        ISSN： 1471-4914            Impact factor:   11.951


  10 in total

1.  Replication and reproducibility in spinal cord injury research.

Authors:  Oswald Steward; Phillip G Popovich; W Dalton Dietrich; Naomi Kleitman
Journal:  Exp Neurol       Date:  2011-11-10       Impact factor: 5.330

2.  The dorsolateral corticospinal tract in mice: an alternative route for corticospinal input to caudal segments following dorsal column lesions.

Authors:  Oswald Steward; Binhai Zheng; Carole Ho; Kim Anderson; Marc Tessier-Lavigne
Journal:  J Comp Neurol       Date:  2004-05-10       Impact factor: 3.215

3.  Perivascular fibroblasts form the fibrotic scar after contusive spinal cord injury.

Authors:  Cynthia Soderblom; Xueting Luo; Ezra Blumenthal; Eric Bray; Kirill Lyapichev; Jose Ramos; Vidhya Krishnan; Catherine Lai-Hsu; Kevin K Park; Pantelis Tsoulfas; Jae K Lee
Journal:  J Neurosci       Date:  2013-08-21       Impact factor: 6.167

4.  A pericyte origin of spinal cord scar tissue.

Authors:  Christian Göritz; David O Dias; Nikolay Tomilin; Mariano Barbacid; Oleg Shupliakov; Jonas Frisén
Journal:  Science       Date:  2011-07-08       Impact factor: 47.728

Review 5.  Pharmacological modification of the extracellular matrix to promote regeneration of the injured brain and spinal cord.

Authors:  Nicole Brazda; Hans Werner Müller
Journal:  Prog Brain Res       Date:  2009       Impact factor: 2.453

6.  Axonal regeneration. Systemic administration of epothilone B promotes axon regeneration after spinal cord injury.

Authors:  Jörg Ruschel; Farida Hellal; Kevin C Flynn; Sebastian Dupraz; David A Elliott; Andrea Tedeschi; Margaret Bates; Christopher Sliwinski; Gary Brook; Kristina Dobrindt; Michael Peitz; Oliver Brüstle; Michael D Norenberg; Armin Blesch; Norbert Weidner; Mary Bartlett Bunge; John L Bixby; Frank Bradke
Journal:  Science       Date:  2015-03-12       Impact factor: 47.728

7.  Transgenic mice for conditional gene manipulation in astroglial cells.

Authors:  Michal Slezak; Christian Göritz; Aurore Niemiec; Jonas Frisén; Pierre Chambon; Daniel Metzger; Frank W Pfrieger
Journal:  Glia       Date:  2007-11-15       Impact factor: 7.452

Review 8.  Axon plasticity in the mammalian central nervous system after injury.

Authors:  Meifan Chen; Binhai Zheng
Journal:  Trends Neurosci       Date:  2014-09-10       Impact factor: 13.837

9.  Ependymal cell contribution to scar formation after spinal cord injury is minimal, local and dependent on direct ependymal injury.

Authors:  Yilong Ren; Yan Ao; Timothy M O'Shea; Joshua E Burda; Alexander M Bernstein; Andrew J Brumm; Nagendran Muthusamy; H Troy Ghashghaei; S Thomas Carmichael; Liming Cheng; Michael V Sofroniew
Journal:  Sci Rep       Date:  2017-01-24       Impact factor: 4.379

10.  Reducing Pericyte-Derived Scarring Promotes Recovery after Spinal Cord Injury.

Authors:  David Oliveira Dias; Hoseok Kim; Daniel Holl; Beata Werne Solnestam; Joakim Lundeberg; Marie Carlén; Christian Göritz; Jonas Frisén
Journal:  Cell       Date:  2018-03-01       Impact factor: 41.582
  10 in total
  4 in total

1.  Systematic analysis of purified astrocytes after SCI unveils Zeb2os function during astrogliosis.

Authors:  Haichao Wei; Xizi Wu; Yanan You; Raquel Cuevas-Diaz Duran; Yiyan Zheng; K Lakshmi Narayanan; Bo Hai; Xu Li; Neha Tallapragada; Tanuj J Prajapati; Dong H Kim; Benjamin Deneen; Qi-Lin Cao; Jia Qian Wu
Journal:  Cell Rep       Date:  2021-02-02       Impact factor: 9.423

Review 2.  Versatile subtypes of pericytes and their roles in spinal cord injury repair, bone development and repair.

Authors:  Sipin Zhu; Min Chen; Yibo Ying; Qiuji Wu; Zhiyang Huang; Wenfei Ni; Xiangyang Wang; Huazi Xu; Samuel Bennett; Jian Xiao; Jiake Xu
Journal:  Bone Res       Date:  2022-03-16       Impact factor: 13.362

3.  Pericytes: Problems and Promises for CNS Repair.

Authors:  Fabio Laredo; Julia Plebanski; Andrea Tedeschi
Journal:  Front Cell Neurosci       Date:  2019-12-06       Impact factor: 5.505

4.  Effects of Combined Admistration of Imatinib and Sorafenib in a Murine Model of Liver Fibrosis.

Authors:  Antonio Pesce; Rosella Ciurleo; Alessia Bramanti; Eliana Concetta Armeli Iapichino; Maria Cristina Petralia; Gaetano Giuseppe Magro; Paolo Fagone; Placido Bramanti; Ferdinando Nicoletti; Katia Mangano
Journal:  Molecules       Date:  2020-09-20       Impact factor: 4.411
  4 in total

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