Piotr Żukowski1, Mateusz Maciejczyk2, Danuta Waszkiel3. 1. Department of Hospital Dentistry, Croydon University Hospital, England, 530 London Road Croydon, Surrey CR7 7YE, United Kingdom. Electronic address: piotr.zukowski@nhs.net. 2. Department of Physiology, Medical University of Bialystok, Mickiewicza 2c Str., 15-222 Bialystok, Poland. Electronic address: mat.maciejczyk@gmail.com. 3. Department of Conservative Dentistry, Medical University Bialystok, Sklodowskiej M.C. 24a Str., 15-274 Bialystok, Poland. Electronic address: danutawaszkiel@poczta.onet.pl.
Abstract
OBJECTIVE: An oral cavity is a place especially susceptible to oxidative damage. It is subjected to many environmental pro-oxidative factors or factors that have the ability to generate reactive oxygen species (ROS). The aim of this article is to present the main sources of ROS and oxidative stress in the oral environment. DESIGN: A literature search was performed using the PubMed and Google Scholar databases. RESULTS: One of the most important ROS sources in the oral cavity is periodontal inflammation. Other sources of ROS include: xenobiotics (ethanol, cigarette smoke, drugs), food (high-fat diet, high-protein diet, acrolein), dental treatment (ozone, ultrasound, non-thermal plasma, laser light, ultraviolet light), and dental materials (fluorides, dental composites, fixed orthodontic appliances, and titanium fixations). It has been shown that excessive production of ROS in the oral cavity may cause oxidative stress and oxidative damage to cellular DNA, lipids, and proteins, thus predisposing to many oral and systemic diseases. CONCLUSIONS: Recognition of the exogenous sources of ROS and limitation of exposure to the ROS generating factors can be one of the prophylactic measures preventing oral and systemic diseases. It is suggested that antioxidant supplementation may be helpful in people exposed to excessive production of ROS in the oral cavity system.
OBJECTIVE: An oral cavity is a place especially susceptible to oxidative damage. It is subjected to many environmental pro-oxidative factors or factors that have the ability to generate reactive oxygen species (ROS). The aim of this article is to present the main sources of ROS and oxidative stress in the oral environment. DESIGN: A literature search was performed using the PubMed and Google Scholar databases. RESULTS: One of the most important ROS sources in the oral cavity is periodontal inflammation. Other sources of ROS include: xenobiotics (ethanol, cigarette smoke, drugs), food (high-fat diet, high-protein diet, acrolein), dental treatment (ozone, ultrasound, non-thermal plasma, laser light, ultraviolet light), and dental materials (fluorides, dental composites, fixed orthodontic appliances, and titanium fixations). It has been shown that excessive production of ROS in the oral cavity may cause oxidative stress and oxidative damage to cellular DNA, lipids, and proteins, thus predisposing to many oral and systemic diseases. CONCLUSIONS: Recognition of the exogenous sources of ROS and limitation of exposure to the ROS generating factors can be one of the prophylactic measures preventing oral and systemic diseases. It is suggested that antioxidant supplementation may be helpful in people exposed to excessive production of ROS in the oral cavity system.
Authors: Marta Żebrowska-Gamdzyk; Mateusz Maciejczyk; Anna Zalewska; Katarzyna Guzińska-Ustymowicz; Anna Tokajuk; Halina Car Journal: Nutrients Date: 2018-08-28 Impact factor: 5.717
Authors: Samira V Gomes; Vandilson Rodrigues; Danila L Nunes-Dos-Santos; Antonio L A Pereira; Marco A Peres Journal: Clin Oral Investig Date: 2021-07-01 Impact factor: 3.573
Authors: Jan Borys; Mateusz Maciejczyk; Bożena Antonowicz; Adam Krętowski; Danuta Waszkiel; Piotr Bortnik; Katarzyna Czarniecka-Bargłowska; Magdalena Kocisz; Julita Szulimowska; Marek Czajkowski; Napoleon Waszkiewicz; Anna Zalewska Journal: Oxid Med Cell Longev Date: 2018-06-14 Impact factor: 6.543