Qiaoyue Tan1,2, Huaiqiang Sun1,3, Weina Wang1, Xintong Wu4, Nanya Hao4, Xiaorui Su1, Xibiao Yang5, Simin Zhang1, Jingkai Su5, Qiang Yue6, Qiyong Gong1. 1. Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, People's Republic of China. 2. Division of Radiation Physics, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital of Sichuan University, Chengdu, People's Republic of China. 3. Research Core Facilities, West China Hospital of Sichuan University, Chengdu, People's Republic of China. 4. Department of Neurology, West China Hospital of Sichuan University, Chengdu, People's Republic of China. 5. Department of Radiology, West China Hospital of Sichuan University, No. 37 Guo Xue Xiang, Chengdu, 610041, Sichuan, People's Republic of China. 6. Department of Radiology, West China Hospital of Sichuan University, No. 37 Guo Xue Xiang, Chengdu, 610041, Sichuan, People's Republic of China. qiangmoon@126.com.
Abstract
OBJECTIVE: To characterize possible metabolic changes of the dorsolateral prefrontal cortex (DLPFC) in patients with temporal lobe epilepsy (TLE). METHODS: Quantitative proton magnetic resonance spectroscopy (1H-MRS) studies were performed on 24 TLE patients and 22 healthy controls. Metabolite concentrations were calculated using a linear combination model (LCModel) and corrected for cerebrospinal fluid contamination. Comparisons were performed between the TLE patients and the controls and between the left DLPFC and right DLPFC in each group. Pearson correlation coefficients were calculated between the metabolite concentrations and epilepsy duration and between the metabolite concentrations and voxel tissue composition: [gray matter (GM)/(GM+white matter (WM))]. RESULTS: Metabolic asymmetry was found in controls between the left and right DLPFC, i.e., the NAA concentration of the left DLPFC was significantly higher than that of the right. However, such metabolic asymmetry was not observed in TLE patients. Compared with the controls, TLE patients showed significantly decreased NAA and Ins, and the reductions were greater in the left DLPFC. No significant correlation was found between the metabolite concentrations and epilepsy duration or between the metabolite concentrations and voxel tissue composition [GM/(GM+WM)]. CONCLUSIONS: This study suggests that TLE can produce metabolic changes to DLPFC that is remote from the seizure focus. KEY POINTS: • Magnetic resonance spectroscopy probes the brain metabolism noninvasively. • Dorsolateral prefrontal reductions in NAA (a neuronal marker) and Ins are observed in TLE. • Temporal lobe epilepsy can result in metabolic changes remote from the seizure focus.
OBJECTIVE: To characterize possible metabolic changes of the dorsolateral prefrontal cortex (DLPFC) in patients with temporal lobe epilepsy (TLE). METHODS: Quantitative proton magnetic resonance spectroscopy (1H-MRS) studies were performed on 24 TLEpatients and 22 healthy controls. Metabolite concentrations were calculated using a linear combination model (LCModel) and corrected for cerebrospinal fluid contamination. Comparisons were performed between the TLEpatients and the controls and between the left DLPFC and right DLPFC in each group. Pearson correlation coefficients were calculated between the metabolite concentrations and epilepsy duration and between the metabolite concentrations and voxel tissue composition: [gray matter (GM)/(GM+white matter (WM))]. RESULTS: Metabolic asymmetry was found in controls between the left and right DLPFC, i.e., the NAA concentration of the left DLPFC was significantly higher than that of the right. However, such metabolic asymmetry was not observed in TLEpatients. Compared with the controls, TLEpatients showed significantly decreased NAA and Ins, and the reductions were greater in the left DLPFC. No significant correlation was found between the metabolite concentrations and epilepsy duration or between the metabolite concentrations and voxel tissue composition [GM/(GM+WM)]. CONCLUSIONS: This study suggests that TLE can produce metabolic changes to DLPFC that is remote from the seizure focus. KEY POINTS: • Magnetic resonance spectroscopy probes the brain metabolism noninvasively. • Dorsolateral prefrontal reductions in NAA (a neuronal marker) and Ins are observed in TLE. • Temporal lobe epilepsy can result in metabolic changes remote from the seizure focus.
Authors: A Sherwin; Y Robitaille; F Quesney; A Olivier; J Villemure; R Leblanc; W Feindel; E Andermann; J Gotman; F Andermann Journal: Neurology Date: 1988-06 Impact factor: 9.910
Authors: R Mark Wellard; Regula S Briellmann; James W Prichard; Ari Syngeniotis; Graeme D Jackson Journal: Epilepsia Date: 2003-06 Impact factor: 5.864